Research Archive

Manipulating Conjugated Polymer Backbone Dynamics through Controlled Thermal Cleavage of Alkyl Side Chains

In this work, the Tgs for CPs are systematically studied with controlled side chain cleavage.

Brush Gels: Where Theory, Simulations, and Experiments Meet

We use a combination of the Flory–Rehner approach, scaling analysis, molecular dynamics simulations, and experimental data for poly(n-butyl acrylate) (PBA) networks swollen in toluene to elucidate the effect of brush strand architecture on the equilibrium swelling ratio, Qeq, the modulus of the swollen gel, Ggel(Qeq), and its relationship with the nonlinear modulus of the dry network, G(Qeq)

Crystallization-Enabled Henry Reactions: Stereoconvergent Construction of Fully Substituted [N]-Asymmetric Centers

This article describes stereoconvergent Henry reactions of γ,γ-disubstituted nitroalkanes to deliver highly functionalized building blocks containing up to five contiguous stereogenic centers including a fully substituted [N]-asymmetric center.

Mechanistic Investigations into Amination of Unactivated Arenes via Cation Radical Accelerated Nucleophilic Aromatic Substitution

A mechanistic investigation into the amination of electron-neutral and electron-rich arenes using organic photoredox catalysis is presented.

Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis

Here, we provide biochemical and bioinformatic evidence in support of the role of a unique class of condensation domains in dehydration (CmodAA).

Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Here, we compare the fecal microbiomes of transplant recipients receiving MMF to healthy individuals using shotgun metagenomic sequencing.

HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/beta-Catenin Signaling

We hypothesized that incorporating physiologically relevant environments would promote post-differentiation patterning of hepatocytes and result in zonal-like characteristics. To test this hypothesis, we evaluated the transcriptional regulation and activity of drug-metabolizing enzymes in HepaRG cells exposed to three different oxygen tensions, in the presence or absence of Wnt/β-catenin signaling.

Aliphatic C-H Functionalization Using Pyridine N-Oxides as H-Atom Abstraction Agents

The alkylation and heteroarylation of unactivated tertiary, secondary, and primary C(sp3)–H bonds was achieved by employing an acridinium photoredox catalyst along with readily available pyridine N-oxides as hydrogen atom transfer (HAT) precursors under visible light.

HFIP in Organic Synthesis

In this review, following a brief history of HFIP in organic synthesis and an overview of its physical properties, literature examples of organic reactions using HFIP as a solvent or an additive are presented, emphasizing the effect of solvent of each reaction.

A dual initiator approach for oxygen tolerant RAFT polymerization

Herein we report a broadly applicable approach to “polymerize through” oxygen using the synergistic combination of two radical initiators having different rates of homolysis.

Initial pH Governs Secondary Organic Aerosol Phase State and Morphology after Uptake of Isoprene Epoxydiols (IEPDX)

Herein, we show distinct differences in the morphology, phase state, and chemical composition of individual organic–inorganic mixed particles after IEPOX uptake to ammonium sulfate particles with different initial atmospherically relevant acidities (pH = 1, 3, and 5).

A structural metagenomics pipeline for examining the gut microbiome

Here, we outline a pipeline that combines microbial whole genome sequencing with protein structure data to yield a structural metagenomics-informed atlas of microbial enzyme families of interest.