Research Analytical

Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas

Here, we show that phosphorus (P) regulates TORC1 signaling in the model green alga Chlamydomonas (Chlamydomonas reinhardtii) via LST8, a conserved TORC1 subunit that interacts with the kinase domain of TOR.

Mapping Solvent Entrapment in Multiphase Systems by Electrogenerated Chemiluminescence

We describe the observation and quantification of immiscible solvent entrapment on a carbonaceous electrode surface using microscopy-coupled electrogenerated chemiluminescence (ECL).

Revealing Dynamic Rotation of Single Graphene Nanoplatelets on Electrified Microinterfaces

Here, we combine optical microscopy, single-entity electrochemistry, and numerical simulations to elucidate the dynamic motion of graphene nanoplatelets at a gold ultramicroelectrode (radius ∼5 μm).

Representative Publications

The Plant Cell.
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Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas Inmaculada Couso, María Esther Pérez-Pérez, Megan M. Ford, Enrique Martínez-Force, Leslie M. Hicks, James G. Umen and José L. Crespo The Plant Cell January 2020 32 (1), 69-80 DOI: 10.1105/tpc.19.00179

Langmuir.
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Mapping Solvent Entrapment in Multiphase Systems by Electrogenerated Chemiluminescence Matthew W. Glasscott, Silvia Voci, Philip J. Kauffmann, Andrei I. Chapoval, and Jeffrey E. Dick Langmuir 2021 37 (9), 2907-2912 DOI: 10.1021/acs.langmuir.0c03445

ACS Nano.
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Biomacromolecules.
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Nitric Oxide-Releasing Hyaluronic Acid as an Antibacterial Agent for Wound Therapy Sara E. Maloney, Kyle V. McGrath, Mona Jasmine R. Ahonen, Daniel S. Soliman, Evan S. Feura, Hannah R. Hall, Shannon M. Wallet, Robert Maile, and Mark H. Schoenfisch Biomacromolecules 2021 22 (2), 867-879 DOI: 10.1021/acs.biomac.0c01583

Bioconjugate Chemistry.
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Theranostic Activity of Nitric Oxide-Releasing Carbon Quantum Dots Haibao Jin, Evan S. Feura, and Mark H. Schoenfisch Bioconjugate Chemistry 2021 32 (2), 367-375 DOI: 10.1021/acs.bioconjchem.1c00002

Journal of Natural Products.
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Multiple Classes of Antimicrobial Peptides in Amaranthus tricolor Revealed by Prediction, Proteomics, and Mass Spectrometric Characterization Tessa B. Moyer, Jessie L. Allen, Lindsey N. Shaw, and Leslie M. Hicks Journal of Natural Products 2021 84 (2), 444-452 DOI: 10.1021/acs.jnatprod.0c01203

ACS Infectious Diseases.
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Exogenous Nitric Oxide Improves Antibiotic Susceptibility in Resistant Bacteria Kaitlyn R. Rouillard, Olivia P. Novak, Alex M. Pistiolis, Lei Yang, Mona J. R. Ahonen, Rebecca A. McDonald, and Mark H. Schoenfisch ACS Infectious Diseases 2021 7 (1), 23-33 DOI: 10.1021/acsinfecdis.0c00337

Environmental Science & Technology Letters.
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μ-MIP: Molecularly Imprinted Polymer-Modified Microelectrodes for the Ultrasensitive Quantification of GenX (HFPO-DA) in River Water Matthew W. Glasscott, Kathryn J. Vannoy, Rezvan Kazemi, Matthew D. Verber, and Jeffrey E. Dick Environmental Science & Technology Letters 2020 7 (7), 489-495 DOI: 10.1021/acs.estlett.0c00341

Nicotine & Tobacco Research.
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Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cellular Membrane Potential Are Predictors of E-Liquid Induced Cellular Toxicity Eva Correia-Álvarez, PhD, James E Keating, BS, Gary Glish, PhD, Robert Tarran, PhD, M Flori Sassano, PhD Nicotine & Tobacco Research 2020 22(2), S4–S13 DOI: 10.1093/ntr/ntaa177

ACS Sensors.
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Electrochemical Sensing of Perfluorooctanesulfonate (PFOS) Using Ambient Oxygen in River Water Rebecca B. Clark and Jeffrey E. Dick ACS Sensors 2020 5 (11), 3591-3598 DOI: 10.1021/acssensors.0c01894

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