Campus Box 3290 Chapel Hill, NC 27599-3290, USA

Research Analytical

Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

Oxygen Tension

Oxygen is a transcriptional regulator responsible for tissue homeostasis and maintenance. Studies relating cellular phenotype with oxygen tension often use hypoxia chambers...

Drug Screening Platform

Many potential chemotherapeutics fail to reach patients. One of the key reasons is that compounds are tested during the drug discovery stage in two-dimensional cell cultures...

Cystic Fibrosis

Researchers in the Shoenfisch Group have employed a simplified diffusion cell methodology to measure the diffusion coefficient...

Representative Publications

Generating Linear Oxygen Gradients Across 3D Cell Cultures with Block-Layered Oxygen Controlled Chips — BLOCCs.
Matthew W. Boyce, William C. Simke, Rachael M. Kenney, and Matthew R. Lockett.
Anal. Methods, 2020, 12, 18-24

Developing a Drug Screening Platform: MALDI-Mass Spectrometry Imaging of Paper-Based Cultures.
Fernando Tobias, Julie C. McIntosh, Gabriel J. LaBonia, Matthew W. Boyce, Matthew R. Lockett, Amanda B. Hummon.
Anal. Chem. 2019, 91, 24, 15370-15376

Nitric Oxide Diffusion through Cystic Fibrosis-Relevant Media and Lung Tissue.
Hall, Jackson R., Maloney, Sara E., Jin, Haibao, Taylor, James B., Schoenfisch, Mark H..
RSC Advances, 2020, Issue 5, Issue in progress

Antibiofilm Efficacy of Nitric Oxide-Releasing Alginates against Cystic Fibrosis Bacterial Pathogens.
Mona Jasmine R. Ahonen, Jamie M. Dorrier, Mark H. Schoenfisch.
ACS Infect. Dis. 2019, 5, 8, 1327-1335

Electrochemical Nitric Oxide Sensors: Principles of Design and Characterization.
Micah D. Brown and Mark H. Schoenfisch.
American Chemical Society, Articles ASAP, September 25, 2019, online

In Vivo Antibacterial Efficacy of Nitric Oxide-Releasing Hyperbranched Polymers against Porphyromonas gingivalis.
Yang, Lei, Jing, Li, Jiao, Yizu, Wang, Lufei, Marchesan, Julie T., Offenbacher, Steven, Schoenfisch, Mark H..
Molecular Pharmaceutics, 16, 9, 4017-4023

Selective and Sensocompatible Electrochemical Nitric Oxide Sensor with a Bilaminar Design.
Micah D. Brown, Mark H. Schoenfisch.
ACS Sens., 2019, 4,7, 1766-1773

Nitric Oxide Therapy for Diabetic Wound Healing.
Maggie J. Malone‚ÄźPovolny, Sara E. Maloney, Mark H. Schoenfisch.
Advanced Healthcare Materials, Volume 8, Issue 12, June 21, 2019

Nitric Oxide-Releasing Alginates as Mucolytic Agents.
Ahonen, Mona Jasmine; Hill, David; Schoenfisch, Mark.
ACS Biomaterials Science & Engineering, Volume: 5, Issue: 7, 3409-3418

Electrosynthesis of High-Entropy Metallic Glass Nanoparticles for Designer, Multi-Functional Electrocatalysis.
Matthew W. Glasscott, Andrew D. Pendergast, Sondrica Goines, Anthony R. Bishop, Andy T. Hoang, Christophe Renault & Jeffrey E. Dick.
Nature Communications 10, Article number: 2650, 2019