Research Analytical

Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

Protein–Peptide Binding Energetics under Crowded Conditions

Nearly all biological processes, including strictly regulated protein–protein interactions fundamental in cell signaling, occur inside living cells where the concentration of macromolecules can exceed 300 g/L.

Ribosomal Antimicrobial Peptide

Ribosomal antimicrobial peptide (AMP) natural products, also known as ribosomally synthesized and post-translationally modified peptides (RiPPs) or host defense peptides, demonstrate....

Photosynthetic Metabolism

As global temperatures climb to historic highs, the far-reaching effects of climate change have impacted agricultural nutrient availability. This has extended to low latitude oceans, where a deficit in both nitrogen and phosphorus stores has led...

Representative Publications

Leveraging orthogonal mass spectrometry based strategies for comprehensive sequencing and characterization of ribosomal antimicrobial peptide natural products.
Tessa B. Moyer, Nicole C. Parsley, Patric W. Sadecki, Wyatt J. Schug, and Leslie M. Hicks.
Nat. Prod. Rep., 2020, Advance Article

Exploring the Diversity of Cysteine-Rich Natural Product Peptides via MS/MS Fingerprint Ions.
Nicole C. Parsley, Owen L. Williams, and Leslie M. Hicks.
J. Am. Soc. Mass Spectrom. 2020, 31, 9, 1833–1843

Photosynthetic Metabolism and Nitrogen Reshuffling Are Regulated by Reversible Cysteine Thiol Oxidation Following Nitrogen Deprivation in Chlamydomonas.
Amanda L. Smythers,Evan W. McConnell, Hailey C. Lewis, Saher N. Mubarek and Leslie M. Hicks.
Plants 2020, 9(6), 784

Mode of Nitric Oxide Delivery Affects Antibacterial Action.
Jackson R. Hall, Kaitlyn R. Rouillard, Dakota J. Suchyta, Micah D. Brown, Mona Jasmine R. Ahonen, Mark H. Schoenfisch.
ACS Biomater. Sci. Eng. 2020, 6, 1, 433-441

Generating Linear Oxygen Gradients Across 3D Cell Cultures with Block-Layered Oxygen Controlled Chips — BLOCCs.
Matthew W. Boyce, William C. Simke, Rachael M. Kenney, and Matthew R. Lockett.
Anal. Methods, 2020, 12, 18-24

Developing a Drug Screening Platform: MALDI-Mass Spectrometry Imaging of Paper-Based Cultures.
Fernando Tobias, Julie C. McIntosh, Gabriel J. LaBonia, Matthew W. Boyce, Matthew R. Lockett, Amanda B. Hummon.
Anal. Chem. 2019, 91, 24, 15370-15376

Nitric Oxide Diffusion through Cystic Fibrosis-Relevant Media and Lung Tissue.
Hall, Jackson R., Maloney, Sara E., Jin, Haibao, Taylor, James B., Schoenfisch, Mark H..
RSC Advances, 2020, Issue 5, Issue in progress

Antibiofilm Efficacy of Nitric Oxide-Releasing Alginates against Cystic Fibrosis Bacterial Pathogens.
Mona Jasmine R. Ahonen, Jamie M. Dorrier, Mark H. Schoenfisch.
ACS Infect. Dis. 2019, 5, 8, 1327-1335

Electrochemical Nitric Oxide Sensors: Principles of Design and Characterization.
Micah D. Brown and Mark H. Schoenfisch.
American Chemical Society, Articles ASAP, September 25, 2019, online

In Vivo Antibacterial Efficacy of Nitric Oxide-Releasing Hyperbranched Polymers against Porphyromonas gingivalis.
Yang, Lei, Jing, Li, Jiao, Yizu, Wang, Lufei, Marchesan, Julie T., Offenbacher, Steven, Schoenfisch, Mark H..
Molecular Pharmaceutics, 16, 9, 4017-4023

Selective and Sensocompatible Electrochemical Nitric Oxide Sensor with a Bilaminar Design.
Micah D. Brown, Mark H. Schoenfisch.
ACS Sens., 2019, 4,7, 1766-1773

Nitric Oxide Therapy for Diabetic Wound Healing.
Maggie J. Malone‐Povolny, Sara E. Maloney, Mark H. Schoenfisch.
Advanced Healthcare Materials, Volume 8, Issue 12, June 21, 2019

Nitric Oxide-Releasing Alginates as Mucolytic Agents.
Ahonen, Mona Jasmine; Hill, David; Schoenfisch, Mark.
ACS Biomaterials Science & Engineering, Volume: 5, Issue: 7, 3409-3418