Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

Brain O2 Levels

Glutamate is ubiquitous throughout the brain and serves as the primary excitatory neurotransmitter...


Published in Analytical Chemistry, researchers in the Jeffrey Dick Group demonstrate a method...

Electrospray Ionization

Extractive electrospray ionization is an ambient ionization technique that allows real-time sampling...

Representative Publications

Screening Estrogen Receptor Modulators in a Paper-Based Breast Cancer Model.
Nathan A. Whitman, Zhi-Wei Lin, Thomas J. DiProspero, Julie C. McIntosh, and Matthew R. Lockett.
Anal. Chem., 2018, 90 (20), pp 11981–11988

Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human-Intestinal-Epithelial-Monolayer Platform.
Yuli Wang, Raehyun Kim, Shee-Hwan J. Hwang, Johanna Dutton, Christopher E. Sims, and Nancy L. Allbritton.
Anal. Chem., 2018, 90 (19), pp 11523–11530

A pH-Sensing Optode for Mapping Spatiotemporal Gradients in 3D Paper-Based Cell Cultures.
Rachael M. Kenney, Matthew W. Boyce, Nathan A. Whitman, Brenden P. Kromhout, and Matthew R. Lockett.
Anal. Chem., 2018, 90 (3), pp 2376–2383

Mechanistic Insights into UV-Initiated Thiol–Ene Reactions on Amorphous Carbon Films.
Catherine G. McKenas, Julia M. Fehr, Benedict Liu, Carrie L. Donley, and Matthew R. Lockett.
J. Phys. Chem. C, 2018, 122 (38), pp 21854–21860

Retention and Surface Diffusion of Model Metabolites on Porous Graphitic Carbon.
Daniel B. Lunn, Young J. Yun, James W. Jorgenson.
Journal of Chromatography A, Volume 1530, 29 December 2017, Pages 112-119

Implementation of High Slurry Concentration and Sonication to Pack High-Efficiency, Meter-Long Capillary Ultrahigh Pressure Liquid Chromatography Columns.
Justin M. Godinho, Arved E. Reising, Ulrich Tallarek, James W. Jorgenson.
Journal of Chromatography A, Volume 1462, 2 September 2016, Pages 165-169

Use of an Open Port Sampling Interface Coupled to Electrospray Ionization for the On-Line Analysis of Organic Aerosol Particles.
Kenneth D. Swanson, Anne L. Worth, Gary L. Glish.
Journal of The American Society for Mass Spectrometry, February 2018, Volume 29, Issue 2, pp 297–303

Distinguishing Linkage Position and Anomeric Configuration of Glucose–Glucose Disaccharides by Water Adduction to Lithiated Molecules.
Matthew T. Campbell, Dazhe Chen, and Gary L. Glish.
Anal. Chem., 2018, 90 (3), pp 2048–2054

Direct Electrochemical Observation of Single Platinum Cluster Electrocatalysis on Ultramicroelectrodes.
Matthew W. Glasscott and Jeffrey E. Dick.
Anal. Chem., 2018, 90 (13), pp 7804–7808

PepSAVI-MS Reveals Anticancer and Antifungal Cycloviolacins in Viola odorata.
Nicole C. Parsley, Christine L. Kirkpatrick, Christopher M. Crittenden, Javad Ghassemi Rad, David W. Hoskin, Jennifer S. Brodbelt, Leslie M. Hicks.
Phytochemistry, 152, (2018), pp 61-70

The Phosphorylated Redox Proteome of Chlamydomonas reinhardtii: Revealing Novel Means for Regulation of Protein Structure and Function.
Evan W. McConnell, Emily G. Werth, Leslie M. Hicks.
Redox Biology, 17, (2018), pp 35–46

Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer.
Wang, Yuli; Kim, Raehyun; Gunasekara, Dulan B.; Reed, Mark I.; DiSalvo, Matthew; Nguyen, Daniel L.; Bultman, Scott J.; Sims, Christopher E.; Magness, Scott T.; Allbritton, Nancy L..
Cellular and Molecular Gastroenterology and Hepatology, 5 (2):113-130

Effects of Glutamate Receptor Activation on Local Oxygen Changes.
Walton LR, Boustead NG, Carroll S, Wightman RM.
ACS Chem Neurosci. 2017 Jul 19; 8 (7): 1598-1608.

Thiol–Ene Modified Amorphous Carbon Substrates: Surface Patterning and Chemically Modified Electrode Preparation.
Catherine G. McKenas, Julia M. Fehr, Carrie L. Donley, and Matthew R. Lockett.
Langmuir, 2016, 32 (41), pp 10529–10536

Nitric Oxide Permselectivity in Electropolymerized Films for Sensing Applications.
Micah D. Brown and Mark H. Schoenfisch.
ACS Sens., 2016, 1 (12), pp 1453–1461

Automated Microraft Platform to Identify and Collect Non-Adherent Cells Successfully Gene-Edited with CRISPR-Cas9.
Peter J. Attayek, Jennifer P. Waugh, Sally A. Hunsucker, Philip J. Grayeski, Christopher E. Sims, Paul M. Armistead, and Nancy L. Allbritton.
Biosensors and Bioelectronics, Volume 91, 2017, Pages 175-182, ISSN 0956-5663.

Use of Ice-Nucleating Proteins To Improve the Performance of Freeze–Thaw Valves in Microfluidic Devices.
Joseph C. Gaiteri, W. Hampton Henley, Nathan A. Siegfried, Thomas H. Linz, and J. Michael Ramsey.
Anal. Chem., 2017, 89 (11), pp 5998–6005

Metal Cationization Extractive Electrospray Ionization Mass Spectrometry of Compounds Containing Multiple Oxygens.
Kenneth D. Swanson, Sandra E. Spencer, and Gary L. Glish.
J. Am. Soc. Mass Spectrom. (2017) 28: 1030.

A Microengineered Collagen Scaffold for Generating a Polarized Crypt-Villus Architecture of Human Small Intestinal Epithelium.
Yuli Wanga, Dulan B. Gunasekara, Mark I. Reed, Matthew DiSalvo, Scott J. Bultman, Christopher E. Sims, Scott T. Magness, Nancy L. Allbritton.
Biomaterials, Volume 128, 2017, Pages 44-55, ISSN 0142-9612

Development of β-Hairpin Peptides for the Measurement of SCF-Family E3 Ligase Activity in Vitro via Ornithine Ubiquitination.
Kaiulani M. Houston, Adam T. Melvin, Gregery S. Woss, Effrat L. Fayer, Marcey L. Waters, and Nancy L. Allbritton.
ACS Omega, 2017, 2 (3), pp 1198–1206

Variables Affecting the Internal Energy of Peptide Ions During Separation by Differential Ion Mobility Spectrometry.
Brandon G. Santiago, Matthew T. Campbell, and Gary L. Glish.
Santiago, B.G., Campbell, M.T. & Glish, G.L. J. Am. Soc. Mass Spectrom. (2017) 28: 2160.

Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels.
Jinsheng Zhou, Yanqian Wang, Laurent D. Menard, Sergey Panyukov, Michael Rubinstein, and J. Michael Ramsey.
Nature Communicationsvolume 8, Article number: 807 (2017)

Coupling Microchip Electrospray Ionization Devices with High Pressure Mass Spectrometry.
William M. Gilliland Jr., J. Scott Mellors, and J. Michael Ramsey.
Anal. Chem., 2017, 89 (24), pp 13320–13325

Evaluation of E-Liquid Toxicity Using an Open-Source High-Throughput Screening Assay.
M. Flori Sassano, Eric S. Davis, James E. Keating, Bryan T. Zorn, Tavleen K. Kochar, Matthew C. Wolfgang, Gary L. Glish, and Robert Tarran.
PLoS Biol 16(3): e2003904.