Research Analytical

Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

Combination of Nitric Oxide Release and Surface Texture for Mitigating the Foreign Body Response

The tissue response to polyurethane (PU)-coated implants employing active and/or passive FBR mitigation techniques was evaluated over a 28 day study in a diabetic swine model.

Amino-Deliquescence and Amino-Efflorescence of Methylammonium Lead Iodide

Here, using in situ spectroscopy and microscopy, we examine the thermodynamics and kinetics of the liquefaction and recrystallization of methylammonium lead iodide (MAPbI3) films with MA0 and find that the phenomena are best described as amino-deliquescence and amino-efflorescence, respectively.

Mapping the plant proteome tools for surveying coordinating pathways

This review highlights recent advances in plant proteomics, with an emphasis on spatially and temporally resolved analysis of post-translational modifications and protein interactions.

Representative Publications

ACS.
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Chemistry of Materials.
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Amino-Deliquescence and Amino-Efflorescence of Methylammonium Lead Iodide Jonathan K. Meyers, Lorenzo Y. Serafin, Andre D. Orr, and James F. Cahoon Chemistry of Materials 2021 33 (10), 3814-3822 DOI: 10.1021/acs.chemmater.1c00967

Emerging Topics in Life Sciences.
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Mapping the plant proteome: tools for surveying coordinating pathways Amanda L. Smythers and Leslie M. Hicks Emerging Topics in Life Sciences 2021 5(2), 203–220 DOI: 10.1042/ETLS20200270

Journal of Chemical Education.
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Modernizing the Analytical Chemistry Laboratory: The Design and Implementation of a Modular Protein-Centered Course Amanda L. Smythers, Megan M. Ford, Dakota G. Hawkins, Megan C. Connor, Kylie C. Lawrence, Caroline R. Stanton, Alton C. Gayton, and Leslie M. Hicks Journal of Chemical Education 2021 98 (5), 1645-1652 DOI: 10.1021/acs.jchemed.0c01269

Analytical Chemistry.
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A Generalized Potentiostat Adaptor for Multiplexed Electroanalysis Rebecca B. Clark, Matthew W. Glasscott, Matthew D. Verber, Jenna C. DeMartino, Anton Netchaev, Jason D. Ray, Eric W. Brown, Erik Alberts, P U Ashvin Iresh Fernando, Lee C. Moores, and Jeffrey E. Dick Analytical Chemistry 2021 93 (20), 7381-7387 DOI: 10.1021/acs.analchem.0c05299

BMC Microbiology.
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Proteomic response of Escherichia coli to a membrane lytic and iron chelating truncated Amaranthus tricolor defensin Tessa B. Moyer, Ashleigh L. Purvis, Andrew J. Wommack and Leslie M. Hicks BMC Microbiology 2021 21(110) DOI: 10.1186/s12866-021-02176-4

Current Opinion in Electrochemistry.
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Electrodeposition in aqueous nanoreactors Matthew W. Glasscott and Jeffrey E. Dick Current Opinion in Electrochemistry 2021 25, 100673 DOI: 10.1016/j.coelec.2020.09.004.

The Plant Cell.
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Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas Inmaculada Couso, María Esther Pérez-Pérez, Megan M. Ford, Enrique Martínez-Force, Leslie M. Hicks, James G. Umen and José L. Crespo The Plant Cell January 2020 32 (1), 69-80 DOI: 10.1105/tpc.19.00179

Langmuir.
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Mapping Solvent Entrapment in Multiphase Systems by Electrogenerated Chemiluminescence Matthew W. Glasscott, Silvia Voci, Philip J. Kauffmann, Andrei I. Chapoval, and Jeffrey E. Dick Langmuir 2021 37 (9), 2907-2912 DOI: 10.1021/acs.langmuir.0c03445

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