Campus Box 3290 Chapel Hill, NC 27599-3290, USA

Research Analytical

Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

Cystic Fibrosis Therapeutic

Colonization of the lungs by biofilm-forming pathogens is a major cause of mortality in cystic fibrosis, CF. In CF patients, these pathogens are difficult...

Measuring Nitric Oxide

Nitric oxide, NO, is a molecule of vast physiological significance, but much remains unknown about the in vivo concentration dependence of its activity...

Promising Gingivitis Treatment

Researchers in the Schoenfisch Group, in collaboration with colleagues from the UNC School of Dentistry's Periodontal, and Oral and Craniofacial departments...

Representative Publications

Antibiofilm Efficacy of Nitric Oxide-Releasing Alginates against Cystic Fibrosis Bacterial Pathogens.
Mona Jasmine R. Ahonen, Jamie M. Dorrier, Mark H. Schoenfisch.
ACS Infect. Dis. 2019, 5, 8, 1327-1335

Electrochemical Nitric Oxide Sensors: Principles of Design and Characterization.
Micah D. Brown and Mark H. Schoenfisch.
American Chemical Society, Articles ASAP, September 25, 2019, online

In Vivo Antibacterial Efficacy of Nitric Oxide-Releasing Hyperbranched Polymers against Porphyromonas gingivalis.
Yang, Lei, Jing, Li, Jiao, Yizu, Wang, Lufei, Marchesan, Julie T., Offenbacher, Steven, Schoenfisch, Mark H..
Molecular Pharmaceutics, 16, 9, 4017-4023

Selective and Sensocompatible Electrochemical Nitric Oxide Sensor with a Bilaminar Design.
Micah D. Brown, Mark H. Schoenfisch.
ACS Sens., 2019, 4,7, 1766-1773

Nitric Oxide Therapy for Diabetic Wound Healing.
Maggie J. Malone‐Povolny, Sara E. Maloney, Mark H. Schoenfisch.
Advanced Healthcare Materials, Volume 8, Issue 12, June 21, 2019

Nitric Oxide-Releasing Alginates as Mucolytic Agents.
Ahonen, Mona Jasmine; Hill, David; Schoenfisch, Mark.
ACS Biomaterials Science & Engineering, Volume: 5, Issue: 7, 3409-3418

Electrosynthesis of High-Entropy Metallic Glass Nanoparticles for Designer, Multi-Functional Electrocatalysis.
Matthew W. Glasscott, Andrew D. Pendergast, Sondrica Goines, Anthony R. Bishop, Andy T. Hoang, Christophe Renault & Jeffrey E. Dick.
Nature Communications 10, Article number: 2650, 2019

Azide‑Alkyne Click Reactions to Prepare Chemically Modified Amorphous Carbon Electrodes.
Julia M. Fehr, Catherine G. McKenas, Benedict Liu, Matthew R.Lockett.
Applied Surface Science, Volume 480, 30 June 2019, Pages 1109-1115