Campus Box 3290 Chapel Hill, NC 27599-3290, USA

Research Analytical

Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

NO-Releasing Polyurethanes

In work published in ACS Applied Materials & Interfaces, Ph.D. student Maggie J. Malone-Povolny in professor Mark Schoenfisch's research group, describe how...

Molecular Transport

The luminal surface of the small intestine is composed of a monolayer of cells overlying a lamina propria comprised of extracellular matrix, ECM, proteins. The ECM provides...

Brain O2 Levels

Glutamate is ubiquitous throughout the brain and serves as the primary excitatory neurotransmitter...

Representative Publications

Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles.
Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles.
ACS Appl. Mater. Interfaces, 2019, 11 (13), pp 12216–12223

Molecular Transport through Primary Human Small Intestinal Monolayers by Culture on a Collagen Scaffold with a Gradient of Chemical Cross-Linking.
Jennifer E. Speer, Dulan B. Gunasekara, Yuli Wang, John K. Fallon, Peter J. Attayek, Philip C. Smith, Christopher E. Sims and Nancy L. Allbritton.
Journal of Biological Engineering, 2019, 13:36

Fine-Tuning Porosity and Time-Resolved Observation of the Nucleation and Growth of Single Platinum Nanoparticles.
Matthew W. Glasscott and Jeffrey E. Dick.
ACS Nano, Article ASAP, Web 10.1021/acsnano.9b00546

“Fix and Assay”: Separating In-Cellulo Sphingolipid Reactions from Analytical Assay in Time and Space Using an Aldehyde-Based Fixative.
Angela Proctor and Nancy L. Allbritton.
Analyst, Volume: 144, Issue: 3, Pages: 961-971, FEB 7, 2019

Paper-Based Transwell Assays: An Inexpensive Alternative to Study Cellular Invasion.
Rachael M. Kenney, Adam Loeser, Nathan A. Whitman, and Matthew R. Lockett.
Analyst, 2019,144, 206-211

Advanced Characterization Techniques for Evaluating Porosity, Nanopore Tortuosity, and Electrical Connectivity at the Single Nanoparticle Level.
Matthew William Glasscott, Andrew David Pendergast, Moinul Choudhury, and Jeffrey E. Dick.
ACS Appl. Nano Mater., Just Accepted Manuscript, DOI: 10.1021/acsanm.8b02051

One-Step Electrodeposition of Ligand-Free PdPt Alloy Nanoparticles from Water Droplets: Controlling Size, Coverage, and Elemental Stoichiometry.
Andrew D.Pendergast, Matthew W.Glasscott, Christophe Renault, Jeffrey E.Dick.
Electrochemistry Communications, Volume 98, January 2019, Pages 1-5

Investigating the Effect of Target of Rapamycin Kinase Inhibition on the Chlamydomonas reinhardtii phosphoproteome – From Known Homologs to New Targets.
Emily G. Werth, Evan W. McConnell, Inmaculada Couso Lianez, Zoee Perrine, Jose L. Crespo, James G. Umen, Leslie M. Hicks.
New Phytologist, Volume221, Issue 1, January 2019, Pages 247-260

A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies.
Dulan B. Gunasekara, Jennifer Speer, Yuli Wang, Daniel L. Nguyen, Mark I. Reed, Nicole M. Smiddy, Joel S. Parker, John K. Fallon, Philip C. Smith, Christopher E. Sims, Scott T. Magness, and Nancy L. Allbritton.
Anal. Chem., 2018, 90 (22), pp 13331–13340

Nitric Oxide-Releasing Cyclodextrins.
Haibao Jin, Lei Yang, Mona Jasmine R. Ahonen, and Mark H. Schoenfisch.
J. Am. Chem. Soc., 2018, 140 (43), pp 14178–14184