Campus Box 3290 Chapel Hill, NC 27599-3290, USA

Research Analytical

Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

Nitric Oxide Sensor

Macrophages mediate mammalian inflammation in part by the release of the gasotransmitter, nitric oxide, NO. Electrochemical methods represent...

Diabetic Wound Healing

Chronic wounds, such as pressure ulcers, vascular ulcers, and diabetic ulcers, affect between 2.4 and 4.5 million people in the United States...

Mucus Reduction

The excessive production of thick, viscous mucus in severe respiratory diseases leads to obstruction of the airways...

Representative Publications

Selective and Sensocompatible Electrochemical Nitric Oxide Sensor with a Bilaminar Design.
Micah D. Brown, Mark H. Schoenfisch.
ACS Sens., 2019, 4,7, 1766-1773

Nitric Oxide Therapy for Diabetic Wound Healing.
Maggie J. Malone‐Povolny, Sara E. Maloney, Mark H. Schoenfisch.
Advanced Healthcare Materials, Volume 8, Issue 12, June 21, 2019

Nitric Oxide-Releasing Alginates as Mucolytic Agents.
Ahonen, Mona Jasmine; Hill, David; Schoenfisch, Mark.
ACS Biomaterials Science & Engineering, Volume: 5, Issue: 7, 3409-3418

Electrosynthesis of High-Entropy Metallic Glass Nanoparticles for Designer, Multi-Functional Electrocatalysis.
Matthew W. Glasscott, Andrew D. Pendergast, Sondrica Goines, Anthony R. Bishop, Andy T. Hoang, Christophe Renault & Jeffrey E. Dick.
Nature Communications 10, Article number: 2650, 2019

Azide‑Alkyne Click Reactions to Prepare Chemically Modified Amorphous Carbon Electrodes.
Julia M. Fehr, Catherine G. McKenas, Benedict Liu, Matthew R.Lockett.
Applied Surface Science, Volume 480, 30 June 2019, Pages 1109-1115

Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles.
Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles.
ACS Appl. Mater. Interfaces, 2019, 11 (13), pp 12216–12223

Molecular Transport through Primary Human Small Intestinal Monolayers by Culture on a Collagen Scaffold with a Gradient of Chemical Cross-Linking.
Jennifer E. Speer, Dulan B. Gunasekara, Yuli Wang, John K. Fallon, Peter J. Attayek, Philip C. Smith, Christopher E. Sims and Nancy L. Allbritton.
Journal of Biological Engineering, 2019, 13:36

Fine-Tuning Porosity and Time-Resolved Observation of the Nucleation and Growth of Single Platinum Nanoparticles.
Matthew W. Glasscott and Jeffrey E. Dick.
ACS Nano, Article ASAP, Web 10.1021/acsnano.9b00546