Analytical Research

Consistently ranked as one of the top analytical programs in the United States over the past four decades, the analytical division is recognized as a world leader in this scientific area.

Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of measurement science through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations, single cell assays, micro- and nanoscale chemical measurement devices, and spectroscopy.

Research projects span a wide range of chemical analysis science, including microvolume separations and analysis, nanomaterials, proteomics, sensors, single cell/molecule analysis, and surface analysis; for examples of active research projects please see the list below.

The division has a strong alumni base with students working across academia, industry, and national labs enabling exciting career opportunities and networking for our graduate students.

Recent Research Results

Fix and Assay

Chemical cytometry using capillary electrophoresis, CE, is a powerful tool for measuring single-cell enzyme activity. However, these measurements...

Transwell Assays

Cellular movement is essential in the formation and maintenance of healthy tissues as well as in disease progression such as tumor metastasis. In work published in Analyst...

Kinase Inhibition

Target of rapamycin, TOR, kinase is a conserved regulator of cell growth whose activity is modulated in response to...

Representative Publications

“Fix and Assay”: Separating In-Cellulo Sphingolipid Reactions from Analytical Assay in Time and Space Using an Aldehyde-Based Fixative.
Angela Proctor and Nancy L. Allbritton.
Analyst, Volume: 144, Issue: 3, Pages: 961-971, FEB 7, 2019

Paper-Based Transwell Assays: An Inexpensive Alternative to Study Cellular Invasion.
Rachael M. Kenney, Adam Loeser, Nathan A. Whitman, and Matthew R. Lockett.
Analyst, 2019,144, 206-211

Advanced Characterization Techniques for Evaluating Porosity, Nanopore Tortuosity, and Electrical Connectivity at the Single Nanoparticle Level.
Matthew William Glasscott, Andrew David Pendergast, Moinul Choudhury, and Jeffrey E. Dick.
ACS Appl. Nano Mater., Just Accepted Manuscript, DOI: 10.1021/acsanm.8b02051

One-Step Electrodeposition of Ligand-Free PdPt Alloy Nanoparticles from Water Droplets: Controlling Size, Coverage, and Elemental Stoichiometry.
Andrew D.Pendergast, Matthew W.Glasscott, Christophe Renault, Jeffrey E.Dick.
Electrochemistry Communications, Volume 98, January 2019, Pages 1-5

Investigating the Effect of Target of Rapamycin Kinase Inhibition on the Chlamydomonas reinhardtii phosphoproteome – From Known Homologs to New Targets.
Emily G. Werth, Evan W. McConnell, Inmaculada Couso Lianez, Zoee Perrine, Jose L. Crespo, James G. Umen, Leslie M. Hicks.
New Phytologist, Volume221, Issue 1, January 2019, Pages 247-260

A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies.
Dulan B. Gunasekara, Jennifer Speer, Yuli Wang, Daniel L. Nguyen, Mark I. Reed, Nicole M. Smiddy, Joel S. Parker, John K. Fallon, Philip C. Smith, Christopher E. Sims, Scott T. Magness, and Nancy L. Allbritton.
Anal. Chem., 2018, 90 (22), pp 13331–13340

Nitric Oxide-Releasing Cyclodextrins.
Haibao Jin, Lei Yang, Mona Jasmine R. Ahonen, and Mark H. Schoenfisch.
J. Am. Chem. Soc., 2018, 140 (43), pp 14178–14184

Screening Estrogen Receptor Modulators in a Paper-Based Breast Cancer Model.
Nathan A. Whitman, Zhi-Wei Lin, Thomas J. DiProspero, Julie C. McIntosh, and Matthew R. Lockett.
Anal. Chem., 2018, 90 (20), pp 11981–11988

Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human-Intestinal-Epithelial-Monolayer Platform.
Yuli Wang, Raehyun Kim, Shee-Hwan J. Hwang, Johanna Dutton, Christopher E. Sims, and Nancy L. Allbritton.
Anal. Chem., 2018, 90 (19), pp 11523–11530

A pH-Sensing Optode for Mapping Spatiotemporal Gradients in 3D Paper-Based Cell Cultures.
Rachael M. Kenney, Matthew W. Boyce, Nathan A. Whitman, Brenden P. Kromhout, and Matthew R. Lockett.
Anal. Chem., 2018, 90 (3), pp 2376–2383