Research Archive

Diverse but desolate landscape of gut microbial azoreductases: A rationale for idiopathic IBD drug response

Here, we chart the scope of the structural and functional diversity of AzoRs in health and in patients with the inflammatory bowel diseases (IBDs) UC and Crohn’s Disease (CD).

Carbodiimide Ring-Opening Metathesis Polymerization

Here we report a strategy that begins to address this limitation founded on a mechanistic discovery: ring-opening metathesis polymerization (ROMP) of carbodiimides followed by carbodiimide derivatization.

Mismatched covalent and noncovalent templating leads to large coiled coil-templated macrocycles

Herein we describe the use of dynamic combinatorial chemistry to self-assemble complex coiled coil motifs. We amide-coupled a series of peptides designed to form homodimeric coiled coils with 3,5-dithiobenzoic acid (B) at the N-terminus and then allowed each B-peptide to undergo disulfide exchange.

Rapid, inexpensive, sequence-independent fluorescent labeling of phosphorothioate DNA

Here, we develop an easy, inexpensive, and sequence-independent method for site-specifically labeling DNA oligonucleotides.

Dataset linking free polyunsaturated fatty acid concentrations in erythrocytes with chronic pain conditions in adults

Circulating polyunsaturated fatty acids (PUFAs) and lipid mediators were extracted from human red blood cells and quantified using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Influence of Geometry on Quasi-Ballistic Behavior in Silicon Nanowire Geometric Diodes

Here, we synthesize silicon NW GDs and fabricate single-NW devices from which significant changes in diode performance are observed from relatively minor changes in geometry.

Design optimization of bifacial perovskite minimodules for improved efficiency and stability

Here we report bifacial minimodules with front efficiency comparable to opaque monofacial counterparts, while gaining additional energy from albedo light.

Multi-Electron Transfer at H-Terminated p-Si Electrolyte Interfaces: Large Photovoltages under Inversion Conditions

Photovoltages for hydrogen-terminated p-Si(111) in an acetonitrile electrolyte were quantified with methyl viologen [1,1′-(CH3)2-4,4′-bipyridinium](PF6)2, abbreviated MV2+, and [Ru(bpy)3](PF6)2, where bpy is 2,2′-bipyridine, that respectively undergo two and three one-electron transfer reductions.

Catalytic reduction of dinitrogen to ammonia using molybdenum porphyrin complexes

Here, we show that oxo and nitrido complexes of molybdenum supported by tetramesitylporphyrin (TMP) are effective precatalysts for catalytic N2 reduction to ammonia, verified by 15N2 labeling studies and other control experiments.

11C-, 12C-, and 13C-cyanation of electron-rich arenes via organic photoredox catalysis

Here, we disclose a mild organophotoredox-catalyzed method for efficient cyanation of a broad spectrum of electron-rich arenes, including abundant and readily available veratroles and pyrogallol trimethyl ethers.

Tunable and Switchable Catalysis Enabled by Cation-Controlled Gating with Crown Ether Ligands

In this Account, the development of design principles for achieving cation-controlled catalysis is described.

Resolving the enthalpy of protein stabilization by macromolecular crowding

To resolve the effect of crowding on protein stability, we use 19F nuclear magnetic resonance spectroscopy to follow the reversible, two-state unfolding thermodynamics of the N-terminal Src homology 3 domain of the Drosophila signal transduction protein drk in the presence of polyethylene glycols (PEGs) of various molecular weights and concentrations.