Research and News Archive
Oxygen is a transcriptional regulator responsible for tissue homeostasis and maintenance. Studies relating cellular phenotype with oxygen tension often use hypoxia chambers...
Many potential chemotherapeutics fail to reach patients. One of the key reasons is that compounds are tested during the drug discovery stage in two-dimensional cell cultures...
Studying the formation of transition metal hydride complexes via proton-coupled electron transfer is important for developing next-generation molecular catalysts...
Researchers in the Shoenfisch Group have employed a simplified diffusion cell methodology to measure the diffusion coefficient...
The Department of Chemistry's Student and Postdoc Wellness, SWELL, committee is excited to announce the launch of their website...
RNA therapeutics developer, Ribometrix, and Vertex Pharmaceuticals Incorporated, NASDAQ:VRTX, have announced that the companies have entered
Jon Meyers, a graduate student in the Cahoon Group, has been awarded the prestigious Dorothy M. and Earl S. Hoffman Award by AVS. Congratulations...
Published in ACS Catalysis, the Gagné Group reports an approach to enhancing the number of valuable compounds one can synthesize...
Colonization of the lungs by biofilm-forming pathogens is a major cause of mortality in cystic fibrosis, CF. In CF patients, these pathogens are difficult...
Earlier this semester, Carolina Chemistry's Frank Leibfarth was selected as a 2019 Chemical & Engineering News's "Talented Twelve..."
Understanding the role of core-electron excitations in water under proton irradiation has become important due to the growing use of proton beams...
Jeromy Rech, a Carolina Chemistry doctoral student, recognizes how influential teaching and mentorship can be in making major life decisions...
Nitric oxide, NO, is a molecule of vast physiological significance, but much remains unknown about the in vivo concentration dependence of its activity...
Researchers in the Schoenfisch Group, in collaboration with colleagues from the UNC School of Dentistry's Periodontal, and Oral and Craniofacial departments...
The advancement of living polymerization methodologies has permitted facile generation of complex macromolecular architectures. Living cationic polymerization is...
With efficiencies of polymer solar cells reaching new heights, finding further methods to increase performance is very important. A typical approach to...
Macrophages mediate mammalian inflammation in part by the release of the gasotransmitter, nitric oxide, NO. Electrochemical methods represent...
Chronic wounds, such as pressure ulcers, vascular ulcers, and diabetic ulcers, affect between 2.4 and 4.5 million people in the United States...
The excitation of photoacids produces powerful proton donors that can trigger proton-coupled electron transfer, PCET, reactions. Coupled to time-resolved...
Chemotherapeutics are an essential component of the therapeutic arsenal employed to treat solid and liquid tumors. However, chemotherapeutic...
Professor David Lawrence was instrumental in developing our "Introduction to Laboratory Safety" course...
The selective functionalization of unactivated C–H bonds is a long-standing challenge in synthetic chemistry...
The excessive production of thick, viscous mucus in severe respiratory diseases leads to obstruction of the airways...
Carbene polymerization provides polyolefins that cannot be readily prepared from olefin monomers. However, controlled and living carbene polymerization...
Under certain conditions, it takes a shorter time to cool a hot system than to cool the same system initiated at a lower temperature...
We introduce and investigate a simple and explicitly mechanical model of Maxwell’s demon, a device that interacts with a memory register, a stream of bits, a thermal...
What is the identity of the true electrocatalytic species? This fundamental question has plagued the molecular electrocatalysis community...
The cellular environment is dynamic and complex, involving thousands of different macromolecules with total concentrations...
On the occasion of Professor Tomas Baer’s 80th birthday, past members of his group reunite for a two-day symposium at UNC Chapel Hill on August 9–10...
UNC Chemistry students and Clare Boothe Luce Fellows, Jill Williamson and Tiffany Crawford, participated in the 18-day leadership seminar...
Creative approaches to the design of catalytic nanomaterials are necessary in achieving environmentally sustainable energy sources...
The stereochemical richness of cellulosic biomass, a biorenewable carbon source, makes it an attractive feedstock for the production of fine chemicals...
Professors Jillian Dempsey and Jeffrey Dick, in partnership with Pine Research are piloted a two-day Cyclic Voltammetry Bootcamp...
The unique properties imparted by planar, rigid aromatic rings in synthetic polymers make these macromolecules useful in a range of applications, including disposable packaging...
Congratulations to Spencer Bradshaw, a chemistry major on the biochem track. Spencer is the recipient of this year's James Maguire Outstanding Junior Award...
Andrew Pendergast, a third-year undergraduate student, majoring in Chemistry, has been selected for the prestigious Goldwater Scholarship. Pendergast hopes to...
The tradition of "Aloha Friday" in the department of chemistry was revived last Friday, when a number of scientists residing in the Genome Science Building...
Iota Sigma PI, the National Honorary Society for Women in Chemistry, has selected Professor Leslie Hicks to receive the 2019 Agnes Fay...
Perfect trapping of light in a subwavelength cavity is a key goal in nanophotonics. Perfect trapping has been realized with optical bound...
Frank Leibfarth, an assistant professor in our department, has been named a Beckman Young Investigator by the Arnold and Mabel Beckman Foundation...
Current chemistries used to modify the surfaces of metal oxide semiconductor films are susceptible to hydrolysis and degrade at high, positive...
The Department of Chemistry Mass Spectrometry Core Laboratory is excited to welcome our newest staff member, Diane Wallace. Diane is a North Carolina
In work published in ACS Applied Materials & Interfaces, Ph.D. student Maggie J. Malone-Povolny in professor Mark Schoenfisch's research group, describe how...
The luminal surface of the small intestine is composed of a monolayer of cells overlying a lamina propria comprised of extracellular matrix, ECM, proteins. The ECM provides...
Porous metal nanoparticles, NPs, are important to a variety of applications. However, robust control over NP porosity is difficult difficult to achieve...
The University Award for the Advancement of Women, UAAW, annual award recognizes people on campus who have elevated the status of women...
AMPED EFRC graduate student Matthew Brady has been selected to receive a U.S. Department of Energy, DOE, Office of Science Graduate Student Research, SCGSR, award...
Two-dimensional perovskites have emerged as more intrinsically stable materials for solar cells. Chemical tuning of spacer organic cations ...
Organic photovoltaics, OPVs, possess the advantageous trait of solution processability, yet OPV blends typically use hazardous chlorinated solvents for processing...
Protein‐based drugs called biologics are among the most effective therapeutic treatments available. However, these drugs are unstable and require refrigerated storage...
Quantum dot surfaces are redox active and are known to influence the electronic properties of nanocrystals, yet the molecular-level...
The tacticity of vinyl polymers has a profound effect on their physical properties. Despite the well-developed stereoselective methods...
Published in the Journal of the American Chemical Society, Ph.D. student Dillon Yost and Professor Yosuke Kanai...
When a finite sample of water experiences tension, it may develop voids – bubbles. Sa Hoon Min, a postdoctoral researcher in the Berkowitz Group, published in...
The methylation states of Lys and Arg represent a particularly challenging set of targets to distinguish selectively in water using synthetic receptors...
Binding functional molecules to nanostructured mesoporous metal oxide surfaces provides a way to derivatize metal oxide semiconductors...
Frank Leibfarth, an assistant professor of Chemistry, has recently been selected to receive the Young Investigator Prize...
Chemical cytometry using capillary electrophoresis, CE, is a powerful tool for measuring single-cell enzyme activity. However, these measurements...
Bacterial β-glucuronidase, GUS, enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut...
Light-harvesting inorganic nanocrystals play an important role in emerging solar energy conversion and optoelectronic devices...
The Office of Graduate Education at the UNC School of Medicine recognized ten faculty members from across UNC-Chapel Hill’s campus as...
Diffuse large B-cell lymphoma, DLBCL, is a heterogeneous disease, and at least one-third of its patients relapse after treatment with the current chemotherapy regimen, R-CHOP...
Cellular movement is essential in the formation and maintenance of healthy tissues as well as in disease progression such as tumor metastasis. In work published in Analyst...
β‐Glucuronidase, GUS, enzymes in the gastrointestinal tract are involved in maintaining mammalian‐microbial symbiosis and can play key roles...
Published in ACS Applied Nano Materials, scientists in the Jeffrey Dick Group, demonstrate quantification of porosity, nanopore tortuosity...
Researchers from the Jeffrey Dick Lab, published in Electrochemistry Communications, present a robust and facile method to produce...
Target of rapamycin, TOR, kinase is a conserved regulator of cell growth whose activity is modulated in response to...
Catalytic processes to generate, or oxidize, fuels such as hydrogen are underpinned by multiple proton-coupled electron transfer...
Undergraduate proficiency exams will be given on Tuesday, January 8, 2019, 10:30 am in Venable/Murray Hall room G202...
Animal models are frequently used for in vitro physiologic and drug transport studies of the colon, but there exists significant pressure...
Carolina Chemistry won the award for "most joggers in a team" as they participated in the annual campus Jingle Bell Run...
The analytical research and development organization at Eli Lilly and Company, has awarded their 2018 Young Investigator Award...
Applications are invited for a non-tenure track teaching faculty position in the Department of Chemistry at the University...
RNA viruses, including major human threats like Dengue, usurp and reprogram host cells using short RNA genomes...
Researchers in the Schoenfisch Group, published in JACS, describe a series of secondary amine-modified cyclodextrin, CD, derivatives was synthesized...
Ligand exchange reactions are commonly used to alter the surface chemistry of metal chalcogenide quantum dots. However, a lack of quantifiable...
The health risks associated with acute and prolonged exposure to estrogen receptor, ER, modulators has led to a concerted effort to...
Two-dimensional, 2D, perovskites, with a formula of (RNH3)2MAn-1PbnI3n+1, have shown impressive photovoltaic device efficiency...
A UNC-Chapel Hill interdisciplinary research team of chemists and biologists has unlocked an important clue in understanding how plant pathogens cause diseases...
Bacteria communicate with one another using small organic molecules as chemical messages. These molecules regulate...
In vitro models of the human intestinal epithelium derived from primary stem cells are much needed for the study of...
Paper-based cultures are an emerging platform for preparing 3D tissue-like structures. Chemical gradients can be imposed...
Click chemistries provide a straightforward means of imparting a desired physical property, reactivity, or function...
Protein−protein interactions are usually studied in dilute buffered solutions with macromolecule...
Strain-induced changes to the electronic structure of nanoscale materials provide a promising avenue for expanding the...
Researchers in the Papanikolas and Cahoon groups have developed a pump–probe microscope capable of...
Congratulations to Kenan Distinguished Professor Matthew Redinbo, who has been selected as one of the University's
Congratulations to Associate Professor Jillian Dempsey, who is the 2018 recipient of the Harry Gray Award for Creative Work in
Strategies for the direct C–H functionalization of amines are valuable as these compounds comprise a number of pharmaceuticals...
The defunctionalization of per-oxygenated compounds has great potential to transform readily available carbohydrate...
Prodigious resources are currently being devoted to control the size and morphology of metal...
Cells survive fluctuations in osmolality by accumulating and depleting highly soluble, usually neutral, small organic...
Benzenoids in principle represent attractive and abundant starting materials for the preparation of...
As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance...
From left to right, graduate students Tiffany Crawford, Rachel Johnson, Breanne Hatfield, and Jill Williamson...
Carolina Chemistry Professor Emeritus and former Chair of the Department of Applied Physical Sciences...
Two-dimensional perovskite quantum wells are generating broad scientific interest because of their potential use in...
Carrier diffusion is imaged in a perovskite film and crystal using a newly developed transient absorption microscope...
Ring expansion provides a powerful way of introducing a heteroatom substituent into a carbocyclic framework. However, such...
Researchers in the Aube Group, published in Organic Letters conclusion, have demonstrated an efficient, metal-free
Inspired by marine siderophores that exhibit a morphological shift upon metal coordination, researchers...
Published in the journal Polymer Chemistry, scientists in the Leibfarth Group is an operationally...
Polyolefins that contain polar functional groups are important materials for next‐generation lightweight engineering...
Active camouflage is widely recognized as a soft-tissue feature, and yet the ability to integrate adaptive coloration and...
Despite the versatility of synthetic chemistry, certain combinations of mechanical softness, strength...
Finally, while the article focuses on studies in which the polymer is paired with fullerene derivatives as the electron...
The commercialization of nonfullerene organic solar cells, OSCs, critically relies on the response under typical operating...
Researchers in the You Group, in collaboration with scientist from UNC's Department of Physics and Astronomy...
Metal-catalyzed olefin hydroarylation is an important, atom economical C–C bond-forming strategy for the synthesis of...
The study of metabolites in biological samples is of high interest for a wide range of biological and...
The benefits of sub-2 micrometer chromatographic supports have largely focused separation technologies...
Kenneth D. Swanson, and Anne L. Worth, graduate students in the Glish Group, present a simple design for...
Researchers in the Glish Group, published in Analytical Chemistry, have developed a method to...
Researchers in the Lockett Group have started working with a group led by Professor Marcey Waters...
According to Professor Matthew Lockett, Lin-Zhi Wei, an undergraduate student in his lab, is a "phenomenal..."
Nonproteinogenic amino acids, NAAs, are widely produced by bacteria, animals, and plants for purposes...
Congratulations to Leslie Hicks, who is this year's winner of the Robert J. Cotter New Investigator Award...
Published in Analytical Chemistry, researchers in the Jeffrey Dick Group demonstrate a method...
Congratulations to Teaching Assistant Professor Brian Hogan, who has been selected for a 2018...
Congratulations to Teaching Assistant Professor Brian Hogan, who has won a 2018 NACADA Award...
Widespread resistance to antimicrobial and cancer therapeutics is evolving in every country worldwide...
Post-translational modifications, PTMs, are covalent modifications to protein residues which may alter both...
Congratulations to Carolina Chemistry! In particular to the staff and leadership at the Undergraduate...
Creating a virtual "Who's Who of Women Analytical Chemists" issue, the journal Analytical Chemistry...
The briarane diterpenes are a class of highly oxygenated marine metabolites that contain a modified...
The Lawrence Lab has developed a light-activated version of an enzyme that has been implicated in cell...
Researchers in the Cahoon Group have reached a new milestone on the way to optical computing, or the use...
In recent years, cytochrome P450s, P450s, and other heme proteins have attracted intense interest...
Diketopiperazines, DKPs, make up a large group of natural products with diverse structures and biological...
Congratulations to Samantha Pizskiewicz in the Pielak Research Group, who has been selected...
The successful culture of intestinal organoids has greatly enhanced our understanding of intestinal stem cell...
Glutamate is ubiquitous throughout the brain and serves as the primary excitatory neurotransmitter...
Amorphous carbon, aC, films are chemically stable under ambient conditions or when interfaced...
There are four well-known levels of protein structure: primary, amino acid sequence, secondary...
Red blood cells, the most numerous type of cell in the body, can act as light-activated drug delivery...
A team led by Professor Yosuke Kanai has received a 2017 Innovative and Novel Computational...
Researchers in the Waters Group, in collaboration with the U.S. Army Research Office...
Nearly every ionic solid consists of positively and negatively charged atoms, but in exotic materials...
Researchers from North Carolina State University, in collaboration with the You Group here at...
In many ways, greenhouses are not all that green. Plants require only certain wavelengths of light...
The effects of small, ~102 Da, and larger, >103 Da, cosolutes on the equilibrium stability...
Kenan Distinguished Professor of Chemistry, Biochemistry and Biophysics, Gary Pielak, has been...
The presence of biological interferents in physiological media necessitates chemical modification...
Collapse of bubbles, microscopic or nanoscopic, due to their interaction with the impinging pressure...
Assistant Professor Matthew Lockett has been awarded the "2016 Eli Lilly and Company Young...
Bo Li, Assistant Professor with Carolina Chemistry, was featured in the "Women in Science Wednesday"...
When Jillian Lee Dempsey was interviewing for faculty positions across the country several years ago...
Excited-state electron-transfer reactions are of essential importance as they provide a means to...
Congratulations to Gerardo Perez-Goncalvez, an undergraduate researcher in the Pielak Group, who...
Published in Scientific Reports, Dr. Kyle Reeves and Professor Yosuke Kanai report their theoretical...
Professor David Nicewicz has been awarded the prestigious "Hirata Award" by the University of...
Organic Chemistry is a required course for programs in chemistry, biology, and many health science...
Professor Jillian Dempsey has been awarded the 2017 J. Carlyle Sitterson Award for Teaching First...
Professor Frank Leibfarth, a recent addition to our faculty, is the recipient of the 2017 3M...
Assistant Professor Alexander Miller has been awarded the 2017 Organometallics Distinguished...
Research Assistant Professor Brian Hogan, who is also the Director for Carolina Covenant and...
The inherent structure of two-dimensional, 2D, materials encompasses a regime where surface and...
Post-translational modifications, PTMs, on histone tails act in diverse combinations in the "histone...
Microraft arrays have been used to screen and then isolate adherent and non-adherent cells with...
Methods for the direct C–H functionalization of aromatic compounds are in demand for a variety...
Alkene halofunctionalization reactions are some of the oldest and most commonly employed...
Currently, reliable valving on integrated microfluidic devices fabricated from rigid materials is...
Translational research made possible by technology developed in our department, has been...
In honor of National Bike Month in May, we would like to recognize and commend our Chemistry...
New antibiotic therapies are in dire need to combat increasing antibiotic resistance. Small molecules...
Chemistry Professor Joe DeSimone is currently on leave from UNC to act as CEO of Carbon, the...
Extractive electrospray ionization is an ambient ionization technique that allows real-time sampling...
Materials informatics is a rapidly emerging data- and knowledge-driven approach for the...
As part of their ongoing investigation into the synthesis of stereochemically complex molecules...
The human small intestinal epithelium possesses a distinct crypt-villus architecture and tissue...
Regulation of the ubiquitin–proteasome system to treat select types of cancer has become a...
The necessity of technical writing often first becomes pronounced during a chemist’s graduate...
Kate Pitman from the Miller Lab has been selected as one of 45 finalists for the 2017 Reaxys Ph.D...
In work published in ChemSusChem, a journal focusing on chemistry, sustainability, energy and...
Thiopeptides are a growing class of ribosomally synthesized and post-translationally modified...
Cellular invasion is the gateway to metastasis, which is the leading cause of cancer-related deaths...
In vitro models for screening new cancer chemotherapeutics often rely on two-dimensional...
Heterocycles are routinely encountered as structural units of biologically active unnatural and...
Microbiome-encoded β-glucuronidase, GUS, enzymes play important roles in human health by...
Since the foundational report from Noyori and co-workers describing the dynamic kinetic...
For nearly twenty years, researchers in the Pielak Group have studied how crowded cell-like...
Growing up in New Jersey, Jillian Dempsey was surrounded by the pharmaceutical industry. It...
The selective, and controllable, modification of complex molecules with disparate functional groups...
Fluorinating conjugated polymers is a widely adopted strategy to enhance the efficiency of...
Direct C–H functionalization of aromatic compounds is a useful synthetic strategy that has...
A former undergraduate research, and recent Master's student in the Pielak Group, Christopher...
An important element in synthetic organic chemistry has been the development and application...
Chemist Bo Li at Carolina Chemistry has received a New Innovator Award from the National...
Differential ion mobility spectrometry, DIMS, devices separate ions on the basis of differences in...
Dye-sensitized photoelectrosynthesis cells, DSPECs, provide a flexible approach for solar water splitting based on...
A $300,000 grant from the Clare Boothe Luce Program will support three new graduate...
Researchers in the Miller Group, published in Organometallics, have investigated and applied the...
Benzenoids, in principle, represent attractive and abundant starting materials for the preparation...
The ability to precisely control the transport of single DNA molecules through a nanoscale...
Frank Leibfarth is one of 43 scientists and engineers from 37 research institutions and small...
Madeline Cooke squats in the dirt and leans over the stacked, wooden two-by-fours supporting...
Mass spectrometry, MS, is a powerful analytical technique due to its sensitivity, versatility, and...
Messenger RNAs, mRNAs, convey genetic information from DNA to the ribosome, serving as...
A recent study by UNC School of Medicine researchers, collaborating with UNC Chemistry's...
The Nobel prize-winning Mizoroki-Heck reaction is one of the premier methods for carbon...
Lead Halide Perovskites, LHPs, have shown remarkable promise for use in photovoltaics...
Professor Marcey Waters with Carolina Chemistry, is being honored for fundamental studies of...
In the late 1950s, researchers inferred that linear polyethylene, PE, crystallized with its chain...
Associate Teaching Professor Brian Hogan has been selected to receive a 2018 Tanner Award for...
Trimethyllysine, Kme3, reader proteins are targets for inhibition due to their role in mediating...
Chris Lennox, a fifth-year graduate student in the Dempsey Group, is first author on a paper...
Researchers in the Brustad Group, published in ChemBioChem, report the engineering...
The rapid release of new tobacco products requires high-throughout quantitative methods to...
With an eye towards developing new catalytic chemistries for the conversion of cellulosic biomass into high...
Fluorination of the donor polymer is a widely accepted method to improve the power conversion efficiency of organic...
The gut microbiota harbor diverse β-Glucuronidase, GUS, enzymes that liberate glucuronic acid, GlcA, sugars from...
Long noncoding RNAs, lncRNAs, are important regulators of gene expression, but their structural...