Research Archive

Mechanisms of Electrochemical N2 Splitting by a Molybdenum Pincer Complex

The viability of electrochemical N2 binding and splitting by a molybdenum(III) pincer complex, (pyPNP)MoBr3 (pyPNP = 2,6-bis(tBu2PCH2)-C5H3N)), is established in this work, providing a foundation for a detailed mechanistic study of electrode-driven formation of the nitride complex (pyPNP)Mo(N)Br.

Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery

Here, we investigated the binding of thiamine and methylene diphosphonic acid (MDP, a soluble structural analogue of pyrophosphate) to the thiamine pyrophosphate riboswitch.

Divergent Reactivity of α,α-Disubstituted Alkenyl Hydrazones: Bench Stable Cyclopropylcarbinyl Equivalents

Herein we report the divergent reactivity of 2,2-dialkyl-3-(E)-alkenyl N-tosylhydrazones using Pd-catalyzed cross-coupling conditions, which enable the Z-selective synthesis of 3-aryl-1,4-dienes and gem-dialkyl vinylcyclopropanes.

Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding

This study describes the development of a two-pronged approach combining genetic code expansion (GCE) and structure–activity relationships (SAR) through systematic variation of both the aromatic binding pocket in the protein and the alkyllysine residues in the peptide to probe inhibitor recognition in the CBX5 chromodomain.

Bio-inspired spectropolarimetric sensor based on tandem organic photodetectors and multi-twist liquid crystals

Here, we demonstrate a bio-inspired spectral and polarization sensor structure based on integrating semitransparent polarization-sensitive organic photovoltaics (P-OPVs) and liquid crystal polymer (LCP) retarders in a tandem configuration.

Amaranthus hypochondriacus seeds as a rich source of cysteine rich bioactive peptides

Here, in silico predictions, proteomics, and simulated gastrointestinal digestions are leveraged to identify digestion resistant CRPs within A. hypochondriacus seeds.

Mapping the Morphological Landscape of Oligomeric Di-block Peptide-Polymer Amphiphiles

We herein present a systematic study of PPA structure-assembly relationships.

An Oxidative Dearomatization Approach to Tetrodotoxin via a Masked ortho-Benzoquinone

Progress toward a stereoselective synthesis of tetrodotoxin (TTX) is presented.

Semi-paracrystallinity in semi-conducting polymers

Prior characterization of some of the best-performing materials for transistor and photovoltaic applications, which are based on polymers with rigid backbones, often resulted in conundrums in which X-ray scattering and microscopy yielded seemingly contradicting results. Here we solve the paradox by introducing a new structural model, i.e., semi-paracrystalline organization.

Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds

Herein, in silico analysis predicted 80-100 Cys-rich AMPs per species from three edible traditional medicinal plants: Linum usitatissimum (flax), Trifolium pratense (red clover), and Sesamum indicum (sesame).

Photochemical H2 Evolution from Bis(diphosphine)nickel Hydrides Enables Low-Overpotential Electrocatalysis

Here we report nickel photoelectrocatalysts for H2 evolution, leveraging visible-light-driven photochemical H2 evolution from bis(diphosphine)nickel hydride complexes.

Spatially resolved quantification of drug metabolism and efficacy in 3D paper-based tumor mimics

Here we describe a workflow in which cell viability, drug penetration, and drug metabolism are quantified in a spatially resolved manner.