Gary Pielak

Gary Pielak

Kenan Distinguished Professor of Chemistry, Biochemistry and Biophysics; Vice Chair of Facilities; Jointly appointed with the School of Medicine

   Genome Sciences Building 3250
  Group Website
  Curriculum Vitae

Research Interests

Protein Biophysics Emphasizing Studies in Living Cells

Research Synopsis

My graduate students and I work in three areas:
High-resolution protein NMR studies in living cells.
Oxidative damage to α-synuclein, a key protein in Parkinson's disease.
Pressure perturbation calorimetry of peptides and proteins.

Professional Background

BS Chem., Bradley U, 1977; PhD Biochemistry, with J. Ivan Legg, Washington State U, 1983; Postdoc with Michael Smith, U British Columbia, 1983-1986; Postdoc with Robert JP Williams, Oxford. 1986-1988; DuPont Young Faculty Award; Morrow Young Faculty Award; NIH Pioneer Award, 2006; National Science Foundation Program Director 2013-2014

Research Group

News & Publications

Nearly all biological processes, including strictly regulated protein–protein interactions fundamental in cell signaling, occur inside living cells where the concentration of macromolecules can exceed 300 g/L.


The tradition of "Aloha Friday" in the department of chemistry was revived last Friday, when a number of scientists residing in the Genome Science Building...