Dorothy Erie

Dorothy Erie

Professor

   Genome Sciences Building 4360
   919-962-6370
   derie@email.unc.edu
  Group Website
  Curriculum Vitae


Research Interests

Scanning Force Microscopy, Biological Chemistry


Research Synopsis

The research in my lab is divided into two main areas:

  1. Atomic force microscopy and fluorescence studies of protein-protein and protein-nucleic acid interactions.
  2. Mechanistic studies of transcription elongation. My research spans the biochemical, biophysical, and analytical regimes.

Listed below is an outline of research topics. More detailed information about each topic is included on my group page.

Atomic Force Microscopy
Studies of the structure-function relationship of protein-protein and protein-DNA interactions related to DNA repair

Fluorescence Spectroscopy
Development of a combined AFM-fluorescence microscope for the study of multi-protein systems
Single-molecule fluorescence spectroscopy of protein-DNA complexes

Transcription Elongation
Transient-state kinetic studies of single and multiple nucleotide incorporation
Characterization of RNA polymerases from thermophilic bacteria

Professional Background

B.S. Louisiana State University, 1982; M.S. University of Wisconsin, 1985; Ph.D., Rutgers, 1989


Research Group

News & Publications

Chemistry Professor, Dorothy Erie, collaborates with researchers to conduct research on how proteins MutL and MutS prevent DNA replication errors by creating an immobile structure that calls more proteins to the site to repair the error

 

Bacterial β-glucuronidase, GUS, enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut...