Research Archive

Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding

This study describes the development of a two-pronged approach combining genetic code expansion (GCE) and structure–activity relationships (SAR) through systematic variation of both the aromatic binding pocket in the protein and the alkyllysine residues in the peptide to probe inhibitor recognition in the CBX5 chromodomain.

Bio-inspired spectropolarimetric sensor based on tandem organic photodetectors and multi-twist liquid crystals

Here, we demonstrate a bio-inspired spectral and polarization sensor structure based on integrating semitransparent polarization-sensitive organic photovoltaics (P-OPVs) and liquid crystal polymer (LCP) retarders in a tandem configuration.

Amaranthus hypochondriacus seeds as a rich source of cysteine rich bioactive peptides

Here, in silico predictions, proteomics, and simulated gastrointestinal digestions are leveraged to identify digestion resistant CRPs within A. hypochondriacus seeds.

Mapping the Morphological Landscape of Oligomeric Di-block Peptide-Polymer Amphiphiles

We herein present a systematic study of PPA structure-assembly relationships.

An Oxidative Dearomatization Approach to Tetrodotoxin via a Masked ortho-Benzoquinone

Progress toward a stereoselective synthesis of tetrodotoxin (TTX) is presented.

Semi-paracrystallinity in semi-conducting polymers

Prior characterization of some of the best-performing materials for transistor and photovoltaic applications, which are based on polymers with rigid backbones, often resulted in conundrums in which X-ray scattering and microscopy yielded seemingly contradicting results. Here we solve the paradox by introducing a new structural model, i.e., semi-paracrystalline organization.

Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds

Herein, in silico analysis predicted 80-100 Cys-rich AMPs per species from three edible traditional medicinal plants: Linum usitatissimum (flax), Trifolium pratense (red clover), and Sesamum indicum (sesame).

Photochemical H2 Evolution from Bis(diphosphine)nickel Hydrides Enables Low-Overpotential Electrocatalysis

Here we report nickel photoelectrocatalysts for H2 evolution, leveraging visible-light-driven photochemical H2 evolution from bis(diphosphine)nickel hydride complexes.

Spatially resolved quantification of drug metabolism and efficacy in 3D paper-based tumor mimics

Here we describe a workflow in which cell viability, drug penetration, and drug metabolism are quantified in a spatially resolved manner.

Mixed Tin-Titanium Oxides by Atomic Layer Deposition on Planar Substrates: Physical and Electronic Structure

Here we describe a workflow in which cell viability, drug penetration, and drug metabolism are quantified in a spatially resolved manner.

Modeling the Size Distribution and Chemical Composition of Secondary Organic Aerosols during the Reactive Uptake of Isoprene-Derived Epoxydiols under Low-Humidity Condition

Here, we implement our latest understanding of IEPOX-SOA formation within a box model to simulate the measured reactive uptake of IEPOX on polydisperse ammonium bisulfate seed aerosols within an environmental Teflon chamber.

Buffers, Especially the Good Kind

Here, I discuss some of the background regarding the genesis of “Good’s buffers”, make a few (disparaging) observations about the non-Good’s buffer, Tris, and suggest that we synthesize new buffers by combining the ideas of Good et al. with results from the past 60 years of protein chemistry.