Here we describe a workflow in which cell viability, drug penetration, and drug metabolism are quantified in a spatially resolved manner.
Here, we implement our latest understanding of IEPOX-SOA formation within a box model to simulate the measured reactive uptake of IEPOX on polydisperse ammonium bisulfate seed aerosols within an environmental Teflon chamber.
Here, I discuss some of the background regarding the genesis of “Good’s buffers”, make a few (disparaging) observations about the non-Good’s buffer, Tris, and suggest that we synthesize new buffers by combining the ideas of Good et al. with results from the past 60 years of protein chemistry.
In an attempt to overcome this limitation, in this work we synthesized a series of anion exchange membranes containing non-covalent cross-links formed by a hydrogen bond donor (methacrylic acid) and a hydrogen bond acceptor (dimethylacrylamide).
The mechanism of a visible light-driven dehalogenation/cyclization reaction was investigated using ruthenium(II), iridium(III) and iron(III) photosensitizers by means of steady-state photoluminescence, time-resolved infrared spectroscopy, and nanosecond/femtosecond transient absorption spectroscopy.
Here, we report the use of two Ir(III) photoredox catalysts to initiate chloride, bromide, and iodide oxidation in organic solvents.
To better understand stress-modulated phosphorylation events contributing to antimicrobial resistance, wild type E. faecalis cells treated with cell wall-active antimicrobials, chlorhexidine or ceftriaxone, were examined via phosphoproteomics.
To tackle this challenge in the context of 19F magnetic resonance imaging (MRI) agents, we pursued a computer-guided materials discovery approach that combines synergistic innovations in automated flow synthesis and machine learning (ML) method development.
This analysis shows that (i) there is only a small fraction of free counterions, f* < 12%; (ii) divalent ions have a strong effect on the renormalization of the excluded volume, reducing it by a factor of 2; and (iii) the effect of divalent counterions is much weaker on the renormalization of the Kuhn length, accounting for an increase of up to 10%.
Here, we propose an experimental setting enabling simultaneous fast-scan cyclic voltammetry (FSCV) and blood oxygenation level-dependent functional magnetic imaging (BOLD fMRI) to measure both local tissue oxygen and dopamine responses, and global BOLD changes, respectively.