Research Archive
![](https://chem.unc.edu/wp-content/uploads/2023/03/Enzymatic-Pyridine-Aromatization-during-Thiopeptide-Biosynthesis.png)
Building on our recent observation of the Bycroft–Gowland intermediate (i.e., the direct product of the [4 + 2]-cycloaddition), we interrogated thiopeptide pyridine synthases using a combination of targeted mutagenesis, kinetic assays, substrate analogs, enzyme–substrate cross-linking, and chemical rescue experiments.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Cooperativity-and-reactivity-properties-of-medium-sized-boron-clusters.png)
In continuation of our previous work of small boron clusters [Phys. Chem. Chem. Phys. 23, 24118 (2021)], we systematically examined the neutral and negatively charged boron clusters Bn/B'n − (nε{8–38}) with planar or quasi-planar conformations, whose exotic properties have aroused considerable interest in the literature.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Reorganization-Energies-for-Interfacial-Electron-Transfer-across-Phenylene-Ethynylene-Rigid-Rod-Bridges.png)
Here, LL is a 4-substituted 2,2-bipyridine (bpy) ligand with varying numbers of conjugated phenylenethynylene bridge units between the bipyridine ring and anchoring group consisting of a bis-carboxylated isophthalic group.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Facet-Impact-of-CuMn2O4-Spinel-Nanocatalysts-on-Enhancement-of-the-Oxygen-Reduction-Reaction-in-Alkaline-Media.png)
To further exploit the potential of non-Pt-group metal-based spinel catalysts for the alkaline oxygen reduction reaction (ORR), a cathodic fuel cell reaction, we hereby report a strategy of ORR improvement by controlling the crystallographic facets of ultra-small CuMn2O4 spinel nanocatalysts through a developed colloidal synthesis approach.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Reorganization-Energies-for-Interfacial-Proton-Coupled-Electron-Transfer-to-a-Water-Oxidation-Catalyst.png)
The reorganization energy (λ) for interfacial electron transfer (ET) and proton-coupled ET (PCET) from a conductive metal oxide (In2O3:Sn, ITO) to a surface-bound water oxidation catalyst was extracted from kinetic data measured as a function of the thermodynamic driving force.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Achieving-Site-Selective-C-O-Bond-Reduction-for-High-Value-Cellulosic-Valorization.png)
This perspective describes key lessons from a program whose goals are to site-selectively deoxygenate cellulose-derived carbohydrates.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Legacy-and-emerging-airborne-per-and-polyfluoroalkyl-substances-PFAS-collected-on-PM2.5-filters-in-close-proximity-to-a-fluoropolymer-manufacturing-facility.png)
We measured airborne PFAS on PM2.5 filters in close proximity to a major fluoropolymer manufacturing facility (Chemours' Fayetteville Works) located near Fayetteville, North Carolina, USA.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Cobalt-Catalyzed-Deaminative-Amino-and-Alkoxycarbonylation-of-Aryl-Trialkylammonium-Salts-Promoted-by-Visible-Light.png)
Herein, we demonstrate an aminocarbonylation of aniline-derived trialkylammonium salts promoted by visible light with a simple cobalt catalyst.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Iodenium-or-Phosphonium.png)
Herein, we use an ensemble of computational tools and methodologies to probe the nature of this ambi-valent bond.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Cation-Controlled-Olefin-Isomerization-Catalysis-with-Palladium-Pincer-Complexes.png)
Palladium(II) pincer complexes with varying amine donor substituents have been prepared and studied in olefin isomerization catalysis.
![](https://chem.unc.edu/wp-content/uploads/2023/03/Ratio-of-Omega-6-Omega-3-Polyunsaturated-Fatty-Acids-Associated-With-Somatic-and-Depressive-Symptoms-in-People-With-Painful-Temporomandibular-Disorder-and-Irritable-Bowel.png)
This cross-sectional study investigated associations between the omega-6/omega-3 PUFA ratio and somatic symptom disturbance and depressive symptoms in a community-based sample of 501 adults and determined whether these associations differed between adults with and without TMD or irritable bowel syndrome (IBS).