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Pielak, Gary

Gary Pielak

Gary Pielak

Kenan Distinguished Professor of Chemistry, Biochemistry and Biophysics; Jointly appointed with the School of Medicine

   Genome Sciences Building 3250
  Group Website
  Curriculum Vitae

Research Interests

Protein Biophysics Emphasizing Studies in Living Cells

Research Synopsis

My graduate students and I work in two areas: High-resolution protein NMR studies in living cells. Biophysics of tardigrade dessication-tolerance proteins.

Professional Background

BS Chem., Bradley U, 1977; PhD Biochemistry, with J. Ivan Legg, Washington State U, 1983; Postdoc with Michael Smith, U British Columbia, 1983-1986; Postdoc with Robert JP Williams, Oxford. 1986-1988; DuPont Young Faculty Award; Morrow Young Faculty Award; NIH Pioneer Award; National Science Foundation Program Director; UNC Lifetime Mentor Award; UNC Medical School Excellence in Basic Science Mentoring Award

Research Group

News & Publications

Here, we show that dried CAHS D gels (i.e., aerogels) retain the structural units of their hydrogels, but the details depend on prelyophilization CAHS concentrations.


We review the use of nuclear magnetic resonance (NMR) spectroscopy to assess the exchange of amide protons for deuterons (HDX) in efforts to understand how high concentration of cosolutes, especially macromolecules, affect the equilibrium thermodynamics of protein stability. 


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