Direct Radiofluorination of Arene C-H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant

Abstract

Herein, we describe an organic photoredox system for direct arene C–H radiofluorination, using a peroxide oxidizing agent and LEDs as the light source. In conjunction with an optimized photocatalyst and a microtubing reactor, this system is applicable to a range of electron-rich aromatics and heteroaromatics. We also demonstrate the feasibility of C–H radiofluorination without an azeotropic drying step, which greatly simplifies the workflow of the labeling process.

Citation

Direct Radiofluorination of Arene C–H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant
Li Wang, Alexander R. White, Wei Chen, Zhanhong Wu, David A. Nicewicz, and Zibo Li
Organic Letters 2020 22 (20), 7971-7975
DOI: 10.1021/acs.orglett.0c02815