Research Archive

Heteroarylation of unactivated C–H bonds suitable for late-stage functionalization

Herein, we report a system that enables direct C–H heteroarylation using a stable, commercially available O-alkenylhydroxamate with heterocyclic sulfone partners.

Efficient Enantio-, Diastereo, E/Z-, and Site-Selective Nickel-Catalyzed Fragment Couplings of Aldehydes, Dienes, and Organoborons

We have developed an efficient site- and stereoselective dicarbofunctionalization fragment coupling between aldehydes, dienes, and arylboronic acids for the synthesis of enantioenriched bis-homoallylic alcohols.

CUREing Biochemistry Lab Monotony

This paper describes an upper-level biochemistry CURE designed to provide students with an introductory experience to graduate-level research by studying a suspected DNA helicase.

Emergence and Breaking of Duality Symmetry in Generalized Fundamental Thermodynamic Relations

This theory provides a de-mechanized foundation for classical and nanothermodynamics and offers a framework for distilling emergence from large data, free from underlying details.

Controversy Continues Over Whether Hot Water Freezes Faster Than Cold

Decades after a Tanzanian teenager initiated study of the “Mpemba effect,” the effort to confirm or refute it is leading physicists toward new theories about how substances relax to equilibrium.

Sloppy gear mechanism for coupled stochastic transportation: From antiequilibrium flow to kinetic selectivity

Here, using a simple kinetic model, we present a counterintuitive antiequilibrium phenomenon in the passive transportation of particles through a narrow tube.

High-throughput discovery of fluoride-ion conductors via a decoupled, dynamic, and iterative (DDI) framework

Fluoride–ion batteries are a promising alternative to lithium–ion batteries with higher theoretical capacities and working voltages, but they have experienced limited success due to the poor ionic conductivities of known electrolytes and electrodes. Here, we report a high-throughput computational screening of 9747 fluoride-containing materials in search of fluoride-ion conductors.

Photoactivatable Reporter to Perform Multiplexed and Temporally Controlled Measurements of Kinase and Protease Activity in Single Cells

Peptide bioreporters were developed to perform multiplexed measurements of the activation of epidermal growth factor receptor kinase (EGFR), Akt kinase (Akt/protein kinase B), and proteases/peptidases in single cells.

Effects of Ligand Shell Composition on Surface Reduction in PbS Quantum Dots

In this work, we evaluated the impacts of both surface-binding head group and ligand backbone on the properties and reactivity of PbS QDs through a partial exchange of native oleate ligands with undec-10-enoic acid, p-toluate, and undec-10-ene-1-thiol to access mixed-shell QDs.

Enabling practical nanoparticle electrodeposition from aqueous nanodroplets

Historically, the cost of nanodroplet-mediated electrodeposition experimentation is prohibitive because practitioners use 0.1 M to 0.5 M tetrabutylammonium perchlorate (TBAP) dissolved in the oil phase (∼10 mL). Here, we show that supporting electrolyte is not necessary for the oil phase.

A Semiconductor-Mediator-Catalyst Artificial Photosynthetic System for Photoelectrochemical Water Oxidation

In fabricating an artificial photosynthesis (AP) electrode for water oxidation, we have devised a semiconductor-mediator-catalyst structure that mimics photosystem II (PSII).

Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase

Here, we characterize a monomodular NRPS, PvfC, encoded by the Pseudomonas virulence factor (pvf) gene cluster that is essential for virulence and signaling in different bacterial species.