Research Archive

Multi-omic analysis of host-microbial interactions central to the gut-brain axis

Here we review foundational studies that defined molecular relationships between the microbiota, neurotransmitters, and the gut-brain axis.

A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories

Here, we report the results of a blind benchmark study assessing eleven analysis tools used to infer kinetic rate constants from smFRET trajectories.

Super-soft, firm, and strong elastomers toward replication of tissue viscoelastic response

Herein, we present the A-g-B brush-like graft copolymer platform as a framework for fabrication of materials with independently tunable softness and firmness, capable of reaching a strength of ∼10 MPa on par with stress-supporting tissues such as blood vessel, muscle, and skin.

Drastic performance improvement of indoor organic photovoltaics using a novel laminated homojunction hole-transport layer

In this paper, an additional PTQ10 homojunction hole transport layer (HTL) is introduced into PTQ10:Y6 OPVs via a simple and effective transfer lamination method.

Global 5′-UTR RNA structure regulates translation of a SERPINA1 mRNA

We show that the 5′-UTR of NM_000295.4 folds into a well-defined multi-helix structural domain. We systematically destabilized mRNA structure across the NM_000295.4 5′-UTR, and measured changes in (SHAPE quantified) RNA structure and cap-dependent translation relative to a native-sequence reporter.

Precyclization Conformer Profiles of −SiR3+- and −Bcat+-Activated Linear Si-Protected Hexitols Explain Condensative Cyclization Selectivities

The condensative cyclization of sp3 C–O bonds in per-silylated hexitols is investigated by computation.

Hydrolytically Stable Ionic Fluorogels for High-Performance Remediation of Per- and Polyfluoroalkyl Substances (PFAS) from Natural Water

Herein, we report a class of polymer networks with a synergistic combination of ionic and fluorous components that serve as granular materials for the removal of anionic PFAS from water.

Mapping the Morphological Landscape of Oligomeric Di-block Peptide-Polymer Amphiphiles

We herein present a systematic study of PPA structure-assembly relationships. PPAs containing oligo(ethyl acrylate) and random-coil peptides were used to determine the role of oligomer molecular weight, dispersity, peptide length, and charge density on self-assembly.

mRNA Display Reaches for the Clinic with New PCSK9 Inhibitor

Herein, we discuss the chemical and pharmacological challenges surmounted in bringing this compound to trials and the current outlook for mRNA display-based therapeutic development.

Bottlebrush Elastomers with Crystallizable Side Chains: Monitoring Configuration of Polymer Backbones in the Amorphous Regions during Crystallization

To understand the transition between the two states, the crystallization process was studied with synchrotron X-ray scattering for a series of brush elastomers with poly(ε-caprolactone) side chains bearing from 7 to 13 repeat units.

Reconfigurable Complementary and Combinational Logic Based on Monolithic and Single-Crystalline Al-Si Heterostructures

Targeting the enhancement of fabrication reproducibility and electrical balancing between operation modes, here a nanoscale Al-Si-Al nanowire heterostructure with single elementary, monocrystalline Al leads and sharp Schottky junctions is implemented.

RAFT Step-Growth Polymerization of Diacrylates

Here, we identified a chain transfer agent (CTA) that rapidly yields single unit monomer inserted (SUMI) CTA adducts with a model acrylate monomer.