Elizabeth Brunk

Elizabeth Brunk

Assistant Professor, Jointly Appointed with the Department of of Pharmacology in the School of Medicine

   Genome Sciences Building
   919-843-7100
   elizabeth_brunk@med.unc.edu
  Group Website


Research Interests

Functional genomics, cancer systems biology, multi-omics, bioinformatics, precision medicine


Research Synopsis

Research in the Brunk laboratory focuses on developing computational methods that accelerate the clarity and utility of omics data in biomedical science. Our aim is understanding the link between genetic/molecular variation and phenotype, both in natural and engineered cellular systems. We approach these topics through the lens of computational biology, machine learning and advanced data integration. Thanks to the growing body of cancer omics data, our methods borrow strength across genomics, transcriptomics, ribosome profiling, proteomics, structural genomics, metabolomics and phenotype variability data.

Our research has uncovered patterns in variants that co-occur in three-dimensional protein space and their downstream, molecular and clinical phenotypes. We also develop methods that explore how cells respond to drugs and genetic engineering. Broadly speaking, we aim to better understand how cells achieve regulation at multiple scales of complexity and which genetic and molecular variants influence this process.

Professional Background