
Dorothy Erie
Professor
Genome Sciences Building 4360
919-962-6370
derie@email.unc.edu
Group Website
Curriculum Vitae
Research Interests
Professional Background
Research Group
Research Synopsis
The research in my lab is divided into two main areas:
- Atomic force microscopy and fluorescence studies of protein-protein and protein-nucleic acid interactions.
- Mechanistic studies of transcription elongation. My research spans the biochemical, biophysical, and analytical regimes.
Listed below is an outline of research topics. More detailed information about each topic is included on my group page.
Atomic Force Microscopy
Studies of the structure-function relationship of protein-protein and protein-DNA interactions related to DNA repair
Fluorescence Spectroscopy
Development of a combined AFM-fluorescence microscope for the study of multi-protein systems
Single-molecule fluorescence spectroscopy of protein-DNA complexes
Transcription Elongation
Transient-state kinetic studies of single and multiple nucleotide incorporation
Characterization of RNA polymerases from thermophilic bacteria
News & Publications

Bacterial β-glucuronidase, GUS, enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut...
The Office of Graduate Education at the UNC School of Medicine recognized ten faculty members from across UNC-Chapel Hill’s campus as...