Genome Sciences Building 4360
Scanning Force Microscopy, Biological Chemistry
B.S. Louisiana State University, 1982; M.S. University of Wisconsin, 1985; Ph.D., Rutgers, 1989
The research in my lab is divided into two main areas:
- Atomic force microscopy and fluorescence studies of protein-protein and protein-nucleic acid interactions.
- Mechanistic studies of transcription elongation. My research spans the biochemical, biophysical, and analytical regimes.
Listed below is an outline of research topics. More detailed information about each topic is included on my group page.
Studies of the structure-function relationship of protein-protein and protein-DNA interactions related to DNA repair
Development of a combined AFM-fluorescence microscope for the study of multi-protein systems
Single-molecule fluorescence spectroscopy of protein-DNA complexes
Transient-state kinetic studies of single and multiple nucleotide incorporation
Characterization of RNA polymerases from thermophilic bacteria