The You Group focuses on the synthesis and characterization of novel multifunctional materials for a variety of applications, predominately in electronics and photonics. Challenges to be addressed include, for example, can a 10% solar cell be made through organic materials? Can single molecules serve as the fundamental unit for electronics and spintronics? Group members are working tirelessly to answer these questions by applying interdisciplinary approaches, including organic and polymer synthesis, surface chemistry, nano-patterning, device fabrication, and physical properties characterization using state-of-the-art instrumentation.
The Jeff Johnson Group focuses on the development of new synthetic methods for the assembly of stereochemically complex small molecules. We are particularly interested in the design and synthesis of tailor-made reagents and catalysts for multicomponent reactions. In our recent investigations of several interesting problems, our continuing interest in the exploitation of ring strain as a source of novel reactivity led us to some mechanistically unusual heterocycle-forming cycloadditions of cyclopropanes and aldehydes. On another front, we are interested in the development of dipolar synthons for the coupling of complementary nucleophilic and electrophilic reaction partners. Our development of silyl glyoxylate reagents is an example of work in this area.
The Chemistry Department's Commencement Ceremony will be held on Sunday, May 10, 2015, at the Friday Center Atrium and Grumman Auditorium immediately following the University-wide Commencement Ceremony.
A reception will begin at 12:00 pm, followed at 1:15 pm by the Chemistry ceremony, consisting of the formal awarding of degrees and presentation of awards to selected undergraduate students.
First, Professor Brian Hogan was recognized with a University Diversity Award, then, just a few days later selected as the 2015 recipient of the Carolina Chiron Award. The former recognizes significant contribution to the enhancement, support and/or furtherance of diversity on our campus and in the community.
The recipient of the Carolina Chiron Award is selected by a committee of undergraduate students, representing a wide range of student groups, considering a large pool of nominations, Professor Hogan was selected for his commitment to students both inside and outside the classroom. They believe that he exemplifies what the Chiron Award stands for: excellence in teaching and going above and beyond to help students succeed. Congratulations, Professor Hogan!
A unique event occurred at Carolina Chemistry on Tuesday, February 18th. We had three graduate students, all from the DeSimone Group, successfully defend their dissertations in the same day. Congratulations and all the best to Doctors Kevin Reuter, Dominica Wong, and Katie Moga!
Biotherapeutics, monoclonal antibodies, mAbs, in particular, represent a multi-billion dollar industry that continues to expand. In order to be used as a therapeutic agent the biomolecule must be rigorously characterized in order to ensure safety, efficacy, and potency. However, the size and complexity of mAbs makes this a challenging task. In work published in Analytical Chemistry, researchers in the Ramsey Group describe an integrated microfluidic capillary electrophoresis-electrospray ionization, CE-ESI, device for the separation of intact monoclonal antibody charge variants with online mass spectrometric, MS, identification.
Schematic for CE-ESI devices with a 23 cm separation channel with an enlarged image of the asymmetric turn tapering. Red channels indicate an APS coating while black channels indicate an APS-PEG450 coating. S: sample reservoir; B: background electrolyte reservoir; SW: sample waste reservoir; EO: electroosmotic pump reservoir.
The surface chemistry utilized in the device channels suppressed the electroosmotic flow and prevented analyte adsorption, eliminating the need for complex background electrolyte additives. The microfluidic ESI interface proved vital to the successful ionization and resulting MS analysis by maintaining fluid flow to generate stable ESI. The effectiveness of the technique was demonstrated with the determination of five charge variants in the separation of Infliximab with an additional two mAbs analyzed to show the general applicability of the approach.
As described in Chemical Science, members of the Dempsey Group, in collaboration with the Meyer Group, used a layer-by-layer procedure to prepare chromophore–catalyst assemblies consisting of phosphonate-derivatized porphyrin chromophores and a phosphonate-derivatized ruthenium water oxidation catalyst on the surfaces of tin oxide and titanium dioxide mesoporous, nanoparticle films. In the procedure, initial surface binding of the phosphonate-derivatized porphyrin is followed in sequence by reaction with a zirconium salt and then with the phosphonate-derivatized water oxidation catalyst.
Fluorescence from both the free base and zinc porphyrin derivatives on tin oxide is quenched; substantial emission quenching of the zinc porphyrin occurs on titanium dioxide. Transient absorption difference spectra provide direct evidence for appearance of the porphyrin radical cation on tin oxide via excited-state electron injection. For the chromophore–catalyst assembly on tin oxide, transient absorption difference spectra demonstrate rapid intra-assembly electron transfer oxidation of the catalyst following excitation and injection by the porphyrin chromophore.
We congratulate Assistant Professor James Cahoon as being one of eighteen national recipients of a David and Lucile Packard Foundation Fellowship. James was elected as one of the nation's most innovative early-career scientists and engineers receiving a 2014 Packard Fellowships for Science and Engineering. Each Fellow will receive a grant of $875,000 over five years to pursue their research.
"The Packard Fellowships are an investment in an elite group of scientists and engineers who have demonstrated vision for the future of their fields and for the betterment of our society," said Lynn Orr, Keleen and Carlton Beal Professor at Stanford University, and Chairman of the Packard Fellowships Advisory Panel. "Through the Fellowships program, we are able to provide these talented individuals with the tools and resources they need to take risks, explore new frontiers and follow uncharted paths."