The Redinbo Laboratory uses the tools of structural, molecular and chemical biology to examine a range of dynamic cellular processes central to human health. Current projects include the discovery of new antimicrobials targeted to drug-resistant bacteria, the design of novel proteins engineered to detect and eliminate toxic chemicals, and the development of small-molecule to cell-based methods to improve anticancer chemotherapeutics. In addition, we continue to focus on determining the crystal structures of macromolecular complexes, including those involving human nuclear receptors central to transcriptional regulation, bacterial proteins involved in DNA manipulation and human cell contact, and enzymes central to key cellular processes.
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Chancellor's Eminent Professor of Chemistry, Joseph DeSimone, has been elected to the Institute of Medicine, one of the highest honors in the fields of health and medicine a U. S. scientist can receive. His election to Institute of Medicine represents the third time he has been named a member of a U. S. National Academy. He was elected to the National Academy of Engineering in 2005 and the National Academy of Sciences in 2012. Fewer than 20 people in history have achieved election to all three U. S. National Academies, and he is the first individual in the state of North Carolina to be named to all three U. S. National Academies.
"DeSimone is a renaissance scientist," said Chancellor Carol L. Folt. "He was the first to successfully adapt manufacturing techniques from the computer industry to make advances in medicine, including next-generation approaches to cancer treatment and diagnosis. He provides a beautiful example of how transcending disciplines can revolutionize science and open up entirely new fields of study. We are very proud of what Professor DeSimone and his students have accomplished. He is a gifted and talented teacher and amazing University citizen."
As announced by Israeli Prime Minister Benjamin Netanyahu on October 6th, Arey Distinguished Professor of Chemistry, Thomas Meyer, is one of two winners of the 2014 Eric and Sheila Samson Prime Minister's Prize for Innovation in Alternative Fuels for Transportation. Professor Meyer is recognized as a world leader in solar fuel research.
The $1 million prize is awarded for breakthrough work into converting solar energy into electricity capable of powering transportation. "We are making a major multi-year effort so that we will not be dependent on fluctuations in the price of oil," Netanyahu said. "This prize gives the researchers true appreciation for their efforts." The Eric and Sheila Samson Prize, totaling $1 million, is the world’s largest monetary prize awarded in the field of alternative fuels, and is granted to scientists who have made critical advancements."
Congratulations to Dr. Meyer on receiving such a prestigious international honor," said UNC Chancellor Carol L. Folt. "Dr. Meyer is a superb example of the kind of innovation we champion here at UNC, using research to solve the world's most pressing problems. By pairing a basic scientific knowledge of photosynthesis with the latest advances in nanotechnology, Dr. Meyer and his team are bringing the world closer than ever to making solar energy a practical, reliable power source."
RNA molecules function as the central conduit of information transfer in biology. To do this, they encode information both in their sequences and in their higher-order structures. Understanding the higher-order structure of RNA remains challenging and slow. In work reported in PNAS and highlighted in Science, Phil Homan in the Weeks Lab led a collaboration that devised a simple, experimentally concise, and accurate approach for examining higher-order RNA structure.
The researchers used massively parallel sequencing to invent an easily implemented single-molecule experiment for detecting through-space interactions and multiple conformations in RNA. This strategy, called RING-MaP, can be used to analyze higher-order RNA structure, detect biologically important hidden states, and refine accurate three-dimensional structure models.
We congratulate Assistant Professor James Cahoon as being one of eighteen national recipients of a David and Lucile Packard Foundation Fellowship. James was elected as one of the nation's most innovative early-career scientists and engineers receiving a 2014 Packard Fellowships for Science and Engineering. Each Fellow will receive a grant of $875,000 over five years to pursue their research.
"The Packard Fellowships are an investment in an elite group of scientists and engineers who have demonstrated vision for the future of their fields and for the betterment of our society," said Lynn Orr, Keleen and Carlton Beal Professor at Stanford University, and Chairman of the Packard Fellowships Advisory Panel. "Through the Fellowships program, we are able to provide these talented individuals with the tools and resources they need to take risks, explore new frontiers and follow uncharted paths."
Assistant Professor Leslie Hicks has been awarded the Arthur C. Neish Young Investigator Award. These awards are given each year by the Phytochemical Society of North America to outstanding early career scientists. The young investigator chosen will present their research at the annual meeting as part of the Arthur C. Neish Young Investigator Mini-symposium. Leslie made her presentation earlier this month at the 53rd Annual Meeting in Raleigh. Congratulations, Leslie!
Chemists have long sought new ways to create energy-rich fuels - ideally via reactions powered by a renewable resource such as the sun. But scientists still have a lot to learn about solar-powered reactions, and a new study by Thomas Eisenhart and Jillian Dempsey sheds light on how they occur. The proton-coupled electron transfer reaction, PCET, is a key light-driven step in the conversion of small molecules into energy-rich fuels. Although prior research has provided a basic understanding of PCET reactions between molecules in their ground states, much less is known about the reactions between electronically excited molecules.
In the article, which made the cover of JACS, and was also featured in JACS Spotlights, the team reports results from a mechanistic study of excited-state PCET reactions between two small molecules, acridine orange and tri-tert-butylphenol. The step-by-step process by which the reaction occurs has not been determined previously, but since each of the reaction components has a unique spectroscopic signature, the researchers can monitor each step with transient absorption spectroscopy. The results help explain the intimate coupling of light absorption with both proton and electron transfer, which the authors say will help pave the way for new avenues in solar fuel production.
Christine Herman, Ph.D., JACS
At the Department of Chemistry, we feel strongly that diversity is crucial to our pursuit of academic excellence, and we are deeply committed to creating a diverse and inclusive community. We support UNC's policy, which states that "the University of North Carolina at Chapel Hill is committed to equality of opportunity and pledges that it will not practice or permit discrimination in employment on the basis of race, color, gender, national origin, age, religion, creed, disability, veteran's status, sexual orientation, gender identity or gender expression."