Researchers in the Aube Group, published in Organic Letters conclusion, have demonstrated an efficient, metal-free variant of the intramolecular FC acylation reaction that simply requires dissolution of a trivially available acyl chloride in HFIP. These results are of both theoretical and practical importance given the stature of the FC acylation reaction in laboratory and industrial scale chemistry.
In comparing the results of the present method with those previously published, these conditions are mild and avoid excesses of harsh acids. The lack of need for an aqueous workup provides a significant practical advantage over classic methods. Although further work to elucidate the mechanism of this reaction is necessary, and underway, the utility of the method for heterocyclic synthesis has been demonstrated and should lead to numerous applications in organic and applied organic chemistry.