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The DNA-guided assembly of biohybrid sequence-defined poly(phosphodiester)s was investigated. These polymers contain long non-natural segments covalently connected to single-stranded DNA sequences. These biohybrid structures were synthesized by automated phosphoramidite chemistry using both nucleoside and abiological phosphoramidite monomers.
This work is focused on the development of poly(diol-co-citrate-co-ascorbate) (POCA) elastomers with tunable properties for coating ePTFE vascular grafts.