Research and News Archive

Dempsey Wins ACS Award

Congratulations to Associate Professor Jillian Dempsey, who is the 2018 recipient of the Harry Gray Award for Creative Work in


Photoredox Catalysis

Strategies for the direct C–H functionalization of amines are valuable as these compounds comprise a number of pharmaceuticals...


Hydroborane Cleavage

The defunctionalization of per-oxygenated compounds has great potential to transform readily available carbohydrate...


Nano Electrodeposition

Prodigious resources are currently being devoted to control the size and morphology of metal...


Osmolyte Research

Cells survive fluctuations in osmolality by accumulating and depleting highly soluble, usually neutral, small organic...


CURE-ious Chemistry

Madeline Cooke squats in the dirt and leans over the stacked, wooden two-by-fours supporting...


Protein Folding

For nearly twenty years, researchers in the Pielak Group have studied how crowded cell-like...


Hanna Gray Fellow

A former undergraduate research, and recent Master's student in the Pielak Group, Christopher...


Brain O2 Levels

Glutamate is ubiquitous throughout the brain and serves as the primary excitatory neurotransmitter...


Write Like a Chemist

The necessity of technical writing often first becomes pronounced during a chemist’s graduate...


Waters AAAS Fellow

Professor Marcey Waters with Carolina Chemistry, is being honored for fundamental studies of...


Hicks Awarded

Congratulations to Leslie Hicks, who is this year's winner of the Robert J. Cotter New Investigator Award...


Exploring Bioactive Peptides

As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance...


Molecular Diversity

Benzenoids in principle represent attractive and abundant starting materials for the preparation of...


Claire Booth Luce Fellows

From left to right, graduate students Tiffany Crawford, Rachel Johnson, Breanne Hatfield, and Jill Williamson...


Undergraduate Excellence

According to Professor Matthew Lockett, Lin-Zhi Wei, an undergraduate student in his lab, is a "phenomenal..."


Samulski Awarded

Carolina Chemistry Professor Emeritus and former Chair of the Department of Applied Physical Sciences...


Energy Transfer Mechanisms

Two-dimensional perovskite quantum wells are generating broad scientific interest because of their potential use in...


Imaging Carrier Diffusion

Carrier diffusion is imaged in a perovskite film and crystal using a newly developed transient absorption microscope...


Ring Expansions of Steroids

Ring expansion provides a powerful way of introducing a heteroatom substituent into a carbocyclic framework. However, such...


Acylation Reaction

Researchers in the Aube Group, published in Organic Letters conclusion, have demonstrated an efficient, metal-free


Continuous-Flow Chemistry

Published in the journal Polymer Chemistry, scientists in the Leibfarth Group is an operationally...


Tobacco Research II

A recent study by UNC School of Medicine researchers, collaborating with UNC Chemistry's...


Amphiphile Self-Assembly

Inspired by marine siderophores that exhibit a morphological shift upon metal coordination, researchers...


Liquid Chromatography

The benefits of sub-2 micrometer chromatographic supports have largely focused separation technologies...


Stress–Strain Behavior

Despite the versatility of synthetic chemistry, certain combinations of mechanical softness, strength...


Gut Microbiome Research

The gut microbiota harbor diverse β-Glucuronidase, GUS, enzymes that liberate glucuronic acid, GlcA, sugars from...


Chameleon-Like Elastomers

Active camouflage is widely recognized as a soft-tissue feature, and yet the ability to integrate adaptive coloration and...


Surpassing 10% Efficiency

The commercialization of nonfullerene organic solar cells, OSCs, critically relies on the response under typical operating...


Lifetime Achievement Award

Kenan Distinguished Professor of Chemistry, Biochemistry and Biophysics, Gary Pielak, has been...


Conjugated Polymer Brushes

Researchers in the You Group, in collaboration with scientist from UNC's Department of Physics and Astronomy...


Organic Solar Cells

Finally, while the article focuses on studies in which the polymer is paired with fullerene derivatives as the electron...


Tobacco Research

The rapid release of new tobacco products requires high-throughout quantitative methods to...


Photoelectrosynthesis

Dye-sensitized photoelectrosynthesis cells, DSPECs, provide a flexible approach for solar water splitting based on...


Polymer Fluorination

Fluorination of the donor polymer is a widely accepted method to improve the power conversion efficiency of organic...


Polyolefin Functionalization

Polyolefins that contain polar functional groups are important materials for next‐generation lightweight engineering...


Cation-π Interactions

Trimethyllysine, Kme3, reader proteins are targets for inhibition due to their role in mediating...


Chiral Pincer Ligands

Metal-catalyzed olefin hydroarylation is an important, atom economical C–C bond-forming strategy for the synthesis of...


New Catalytic Chemistries

With an eye towards developing new catalytic chemistries for the conversion of cellulosic biomass into high...


Protein-Protein Interactions

The effects of small, ~102 Da, and larger, >103 Da, cosolutes on the equilibrium stability...


Separation of Metabolites

The study of metabolites in biological samples is of high interest for a wide range of biological and...


Dissertation Fellowship

Congratulations to Samantha Pizskiewicz in the Pielak Research Group, who has been selected...


Switchable Ligation

Researchers in the Miller Group, published in Organometallics, have investigated and applied the...


Molecular Diversity

Benzenoids, in principle, represent attractive and abundant starting materials for the preparation...


Threading Macromolecules

The ability to precisely control the transport of single DNA molecules through a nanoscale...


Shrinking Mass Spec

Mass spectrometry, MS, is a powerful analytical technique due to its sensitivity, versatility, and...


Lead Halide Perovskites

Lead Halide Perovskites, LHPs, have shown remarkable promise for use in photovoltaics...


Proton Acceptors

Chris Lennox, a fifth-year graduate student in the Dempsey Group, is first author on a paper...


Orthogonal Expression

Researchers in the Brustad Group, published in ChemBioChem, report the engineering...


DIMS Fragmentation

Differential ion mobility spectrometry, DIMS, devices separate ions on the basis of differences in...


Peptide-Based Reporters

Regulation of the ubiquitin–proteasome system to treat select types of cancer has become a...


Material Informatics

Materials informatics is a rapidly emerging data- and knowledge-driven approach for the...


Electrospray Ionization

Extractive electrospray ionization is an ambient ionization technique that allows real-time sampling...


Chemistry and Adidas

Chemistry Professor Joe DeSimone is currently on leave from UNC to act as CEO of Carbon, the...


Metal Chelating Antibiotic

New antibiotic therapies are in dire need to combat increasing antibiotic resistance. Small molecules...


Cycling Chemists

In honor of National Bike Month in May, we would like to recognize and commend our Chemistry...


Collagen Scaffold

The human small intestinal epithelium possesses a distinct crypt-villus architecture and tissue...


Translational Research

Translational research made possible by technology developed in our department, has been...


Valving Microfluidic Devices

Currently, reliable valving on integrated microfluidic devices fabricated from rigid materials is...


Alkene Halofunctionalization

Alkene halofunctionalization reactions are some of the oldest and most commonly employed...


Fluorogenic Sensor Platform

Post-translational modifications, PTMs, on histone tails act in diverse combinations in the "histone...


Direct C–H Cyanation

Methods for the direct C–H functionalization of aromatic compounds are in demand for a variety...


Automated Microraft

Microraft arrays have been used to screen and then isolate adherent and non-adherent cells with...


Controlling Phosphorene

The inherent structure of two-dimensional, 2D, materials encompasses a regime where surface and...


Hogan to ASU GSV Summit

Research Assistant Professor Brian Hogan, who is also the Director for Carolina Covenant and...


Miller Distinguished Author

Assistant Professor Alexander Miller has been awarded the 2017 Organometallics Distinguished...


Leibfarth Awarded

Professor Frank Leibfarth, a recent addition to our faculty, is the recipient of the 2017 3M...


Teaching Award to Dempsey

Professor Jillian Dempsey has been awarded the 2017 J. Carlyle Sitterson Award for Teaching First...


Chemical Education Research

Organic Chemistry is a required course for programs in chemistry, biology, and many health science...


Nicewicz Awarded

Professor David Nicewicz has been awarded the prestigious "Hirata Award" by the University of...


Proton Irradiation

Published in Scientific Reports, Dr. Kyle Reeves and Professor Yosuke Kanai report their theoretical...


Caltech WAVE Fellow

Congratulations to Gerardo Perez-Goncalvez, an undergraduate researcher in the Pielak Group, who...


Dynamic Electron Transfer

Excited-state electron-transfer reactions are of essential importance as they provide a means to...


Young Faculty Thrive

When Jillian Lee Dempsey was interviewing for faculty positions across the country several years ago...


Bo Li in endeavors

Bo Li, Assistant Professor with Carolina Chemistry, was featured in the "Women in Science Wednesday"...


Young Investigator Award

Assistant Professor Matthew Lockett has been awarded the "2016 Eli Lilly and Company Young...


Nanobubbles and Cavitation

Collapse of bubbles, microscopic or nanoscopic, due to their interaction with the impinging pressure...


Nitric Oxide Permselectivity

The presence of biological interferents in physiological media necessitates chemical modification...


Off-the-Grid Greenhouses

In many ways, greenhouses are not all that green. Plants require only certain wavelengths of light...


Better Solar Cells

Researchers from North Carolina State University, in collaboration with the You Group here at...


2D Electride

Nearly every ionic solid consists of positively and negatively charged atoms, but in exotic materials...


NCN-Coupled Functions

Researchers in the Waters Group, in collaboration with the U.S. Army Research Office...


DOE INCITE Award

A team led by Professor Yosuke Kanai has received a 2017 Innovative and Novel Computational...


Light-Controlled Drugs

Red blood cells, the most numerous type of cell in the body, can act as light-activated drug delivery...


RNA Structure in Cells

Long noncoding RNAs, lncRNAs, are important regulators of gene expression, but their structural...


Protein Quinary Structure

There are four well-known levels of protein structure: primary, amino acid sequence, secondary...


Amorphous Carbon

Amorphous carbon, aC, films are chemically stable under ambient conditions or when interfaced...


Human Colonic Crypt Array

The successful culture of intestinal organoids has greatly enhanced our understanding of intestinal stem cell...


Synthesis of Briarane Diterpenes

The briarane diterpenes are a class of highly oxygenated marine metabolites that contain a modified...


Analytical Who's Who

Creating a virtual "Who's Who of Women Analytical Chemists" issue, the journal Analytical Chemistry...


GenX Detection

Researchers in the Lockett Group have started working with a group led by Professor Marcey Waters...


Antibiotic Bicyclomycin

Diketopiperazines, DKPs, make up a large group of natural products with diverse structures and biological...


Enzymatic Cyclopropanation

In recent years, cytochrome P450s, P450s, and other heme proteins have attracted intense interest...


Nanoscale Light Switch

Researchers in the Cahoon Group have reached a new milestone on the way to optical computing, or the use...


Compartmentalized Signaling

The Lawrence Lab has developed a light-activated version of an enzyme that has been implicated in cell...


Structure and Function

Post-translational modifications, PTMs, are covalent modifications to protein residues which may alter both...


Medicinal Violets

Widespread resistance to antimicrobial and cancer therapeutics is evolving in every country worldwide...


Ultramicroelectrodes

Published in Analytical Chemistry, researchers in the Jeffrey Dick Group demonstrate a method...


Nonproteinogenic Amino Acid

Nonproteinogenic amino acids, NAAs, are widely produced by bacteria, animals, and plants for purposes...


Anomeric Configuration

Researchers in the Glish Group, published in Analytical Chemistry, have developed a method to...


Open Port Sampling

Kenneth D. Swanson, and Anne L. Worth, graduate students in the Glish Group, present a simple design for...


Public Service Award

Congratulations to Teaching Assistant Professor Brian Hogan, who has been selected for a 2018...


NACADA Award Winner

Congratulations to Teaching Assistant Professor Brian Hogan, who has won a 2018 NACADA Award...


Greenovation Award

Congratulations to Carolina Chemistry! In particular to the staff and leadership at the Undergraduate...


Molecular Assemblies

In work published in ChemSusChem, a journal focusing on chemistry, sustainability, energy and...


Promiscuous Enzymes

Thiopeptides are a growing class of ribosomally synthesized and post-translationally modified...


3D Cultures

Cellular invasion is the gateway to metastasis, which is the leading cause of cancer-related deaths...


Chemotherapeutics Model

In vitro models for screening new cancer chemotherapeutics often rely on two-dimensional...


Cycloadditive Reactions

Heterocycles are routinely encountered as structural units of biologically active unnatural and...


A Microbiome Atlas

Microbiome-encoded β-glucuronidase, GUS, enzymes play important roles in human health by...


Enantioconvergent Reactions

Since the foundational report from Noyori and co-workers describing the dynamic kinetic...


Selective Transformations

The selective, and controllable, modification of complex molecules with disparate functional groups...


C–H Functionalization

Direct C–H functionalization of aromatic compounds is a useful synthetic strategy that has...


Catalyst–Oxide Assemblies

An important element in synthetic organic chemistry has been the development and application...


Glycolic Acid Scaffolds

As part of their ongoing investigation into the synthesis of stereochemically complex molecules...


Bo Li NIH Awardee

Chemist Bo Li at Carolina Chemistry has received a New Innovator Award from the National...


Performance by Fluorination

Fluorinating conjugated polymers is a widely adopted strategy to enhance the efficiency of...


Powering the Future

Growing up in New Jersey, Jillian Dempsey was surrounded by the pharmaceutical industry. It...


Pitman Reaxys Finalist

Kate Pitman from the Miller Lab has been selected as one of 45 finalists for the 2017 Reaxys Ph.D...


Tanner Awardee

Associate Teaching Professor Brian Hogan has been selected to receive a 2018 Tanner Award for...


In With the New!

In the late 1950s, researchers inferred that linear polyethylene, PE, crystallized with its chain...


Auto-Tandem Catalysis

The Nobel prize-winning Mizoroki-Heck reaction is one of the premier methods for carbon...


mRNA Structure Revealed

Messenger RNAs, mRNAs, convey genetic information from DNA to the ribosome, serving as...


Air Force Grant

Frank Leibfarth is one of 43 scientists and engineers from 37 research institutions and small...


STEM Grant

A $300,000 grant from the Clare Boothe Luce Program will support three new graduate...