Department News

Marcey Waters receives Vincent du Vigneaud Award from American Peptide Society

We are pleased to congratulate Marcey Waters on receiving the 2023 Vincent du Vigneaud Award.

Alex Zhukhovitskiy receives 2023 Thieme Chemistry Journals Award

We are pleased to congratulate Alex Zhukhovitskiy on being recognized for his work by Thieme Chemistry Journals.

Brunk Selected to Receive Junior Faculty Development Award

Congratulations to Elizabeth Brunk for receiving a 2023 Junior Faculty Development Award.

Sidney Wilkerson-Hill, Danielle Zurcher, and Gary Pielak earn 2023 University Teaching Awards

We are pleased to share that Sidney Wilkerson-Hill, Assistant Professor, Danielle Zurcher, Teaching Assistant Professor, and Gary Pielak, Kenan Distinguished Professor, earned 2023 University Teaching Awards!

Research

Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis

Here, we provide biochemical and bioinformatic evidence in support of the role of a unique class of condensation domains in dehydration (CmodAA).

Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Here, we compare the fecal microbiomes of transplant recipients receiving MMF to healthy individuals using shotgun metagenomic sequencing.

HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/beta-Catenin Signaling

We hypothesized that incorporating physiologically relevant environments would promote post-differentiation patterning of hepatocytes and result in zonal-like characteristics. To test this hypothesis, we evaluated the transcriptional regulation and activity of drug-metabolizing enzymes in HepaRG cells exposed to three different oxygen tensions, in the presence or absence of Wnt/β-catenin signaling.

Aliphatic C-H Functionalization Using Pyridine N-Oxides as H-Atom Abstraction Agents

The alkylation and heteroarylation of unactivated tertiary, secondary, and primary C(sp3)–H bonds was achieved by employing an acridinium photoredox catalyst along with readily available pyridine N-oxides as hydrogen atom transfer (HAT) precursors under visible light.

Our Faculty

Faculty in the Department of Chemistry at the University of North Carolina help define solutions to the pressing scientific problems of the day. A significant and key component of our department’s strategic plan is to cultivate the next generation of scientific leadership. Faculty, from our assistant professors to our most senior and distinguished colleagues, are international leaders in their subfields, garnering local, national, and international recognition and accolades commensurate with their excellence in research and teaching.

Our Graduate Students

Our graduate students form the next generation of scientific leaders. As a department, we seek to recruit and mentor a diverse cohort of students dedicated to excellence in the classroom and research laboratory. The creativity, drive, collegiality, and accomplishments of our graduate students in tackling difficult scientific problems are significant reasons why UNC is an international leader in chemical research.

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